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Prediction of in-vitro dissolution and tablet hardness from optical porosity measurements
Abstract
Advanced manufacturing technologies such as continuous processing require fast information on the quality of intermediates and products. Process analytical technologies (PAT) to monitor many critical quality attributes (CQAs) have been developed and successfully implemented in…
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3D Screen Printing Offers Unprecedented Anticounterfeiting Strategies for Oral Solid Dosage Forms…
Abstract
A threat to human health in developed and, in particular, in developing countries, counterfeit medicines represent the largest identified fraud market worldwide. 3D screen printing (3DSP), an additive manufacturing technology that enables large-scale production, offers unique opportunities…
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Dissolving microarray patches for transdermal delivery of risperidone for schizophrenia management
Schizophrenia is a psychiatric disorder that results from abnormal levels of neurotransmitters in the brain. Risperidone (RIS) is a common drug prescribed for the treatment of schizophrenia. RIS is a hydrophobic drug that is typically administered orally or intramuscularly. Transdermal drug delivery…
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Hybrid models to support development of fluid bed granulation processes
Abstract
The hybrid modeling strategy which is based on the integration of mechanistic and data-driven models is proposed and applied on fluidized bed granulation processes. The tight combination of empirical process knowledge by means of a mechanistic model and the multivariate data from PAT…
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MEDELPHARM Science Lab | Video Series
MEDELPHARM is passionate about designing and manufacturing easy-to-use, fast, reliable equipment for R&D specialists.
For formulation scientists looking for assistance in powder characterization, solid dosage formulation or production troubleshooting, MEDELPHARM offers a comprehensive…
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Development of emulgel formulation from Markhamia tomentosa leaf extract: Characterization and in…
Abstract
Objectives:
Skin infections are mild to severe infections often treated with antimicrobial agents. There is an increase in resistance to antimicrobial agents necessitating the search for new medicines. This study developed an emulgel formulation of Markhamia tomentosa leaf extract and…
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Synergistic effect of polymers in stabilizing amorphous pretomanid through high drug loaded…
Pretomanid (PTM), an oral antibiotic used in the treatment of adults with pulmonary extensively drug-resistant, nonresponsive multidrug-resistant tuberculosis (MDR-TB). It is a poor glass former, that shows high recrystallization tendency from the amorphous and supersaturated state, resulting in low…
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Multi-component mixing and demixing model for predictive finite element modelling of pharmaceutical…
A set of numerical methods is described that allows predictive finite element method (FEM) simulations of the compaction of multi-component pharmaceutical powder formulations across the entire range of compositions. An automated parametrisation procedure was used to extract density-dependent…
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pH Independent Bi-layer Self-microemulsifying Tablets (SMETs) of Candesartan Cilexetil with…
INTRODUCTION
CANDESARTAN CILEXETIL (CDC)
An angiotensin II receptor antagonist is a prodrug which gets converted to active drug Candersartan during absorption from the gastrointestinal tract.
The conventional CDC tablets have a significantly low bioavailability of approximately 14% after oral…
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Self-Nano-Emulsifying Drug-Delivery Systems: A Limelight on the Development, Advancements and…
Abstract
Back ground: Orally administered medication solubility is a key concern for the pharmaceutical business; about 35-40% of newly introduced pharmaceuticals have less aqueous solubility, resulting in deprived dissolution and limited bio-availability. Employment of lipid-oriented drug release…
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