Browsing Category
Pfanstiehl
Lyophilisation Improves Bioactivity and Stability of Insulin-Loaded Polymeric-Oligonucleotide…
The oral bioavailability of therapeutic proteins is limited by the gastrointestinal barriers. Encapsulation of labile proteins into nanoparticles is a promising strategy. In order to improve the stability of nanoparticles, lyophilisation has been used to remove water molecules from the suspension.…
Read More...
Read More...
Pfanstiehl Inc, USA- Helping accelerate COVID19 research to develop Vaccine, Diagnosis and Cure
Pfanstiehl (IL, USA) is a global leader in developing High Pure/Low Endotoxin Viral Vector, Protein and Vaccine stabilizers ( eg. HPLE-Trehalose, Sucrose, Histidine, Arginine ,Mannitol, Sodium Succinate etc.) that are used in producing many human vaccines and diagnostics worldwide.
As the global…
Read More...
Read More...
A Theoretical Study on Trehalose + Water Mixtures for Dry Preservation Purposes
The properties of trehalose + water mixtures are studied as a function of mixture composition and temperature using molecular dynamics simulations. As trehalose disaccharide has been proposed for dry preservation purposes, the objective of this work is to analyse the nanoscopic properties of the…
Read More...
Read More...
Formation of protein sub-visible particles during powder grinding of a monoclonal antibody
We have observed an interesting phenomenon in which grinding of freeze-dried monoclonal antibody X (mAb-X) formulation powder resulted to significant protein sub-visible particles (SbVPs) in the reconstituted liquid, which could only be observed by sensitive particle analytical methods such as MFI…
Read More...
Read More...
Use of a temperature ramp approach (TRA) to design an optimum and robust freeze-drying process for…
Freeze-drying, until now, has been a process that was designed using a trial and error experimental approach. This approach is often material and time consuming, and the resulting freeze-drying processes are neither optimum nor robust. Accordingly, the objective of this study was to develop a…
Read More...
Read More...
The protection effect of trehalose on the multinuclear microcapsules based on gelatin and high…
Drying of coacervates can cause various stresses which may lead to the damage of the outer layer membrane, aggregation, and poor rehydration properties. Gelatin/pectin coacervates prepared with addition of trehalose as cryoprotectant were subjected to freeze-drying. The addition of trehalose (15%)…
Read More...
Read More...
Trehalose Conjugated, Catechin Loaded Polylactide Nanoparticle for Improved Neuroprotection against…
Intracellular/extracellular protein aggregation is linked to variety of neurodegenerative diseases. Current research focusses on identifying anti-amyloidogenic small molecules to inhibit such protein aggregation and associated cytotoxicity. We have recently demonstrated that transforming those…
Read More...
Read More...
Protective Effect of Saccharides on Freeze-Dried Liposomes Encapsulating Drugs
The production of freeze-dried liposomes encapsulating drugs is considered a key challenge since the drugs are prone to leakage.
The aim of this work was to study the effect of different saccharides on preserving the stability and drug retention capacity of a previously developed liposomal…
Read More...
Read More...
Fast Dissolving Tablets – An Updated Review
Fast dissolving tablets (FDTs) is one of the most widely accepted and popular dosage form, especially for paediatric and geriatric patients. Conventional solid dosage forms like tablets and capsules are facing the problems like difficulty in swallowing (dysphasia), resulting in many incidences of…
Read More...
Read More...
Globular protein stabilized nanoparticles for delivery of disulfiram: fabrication, characterization,…
Disulfiram (DSF), an FDA-approved anti-alcoholic drug, has recently shown that it possesses anti-cancer effects. However, DSF is hydrophobic in nature with less stability. Therefore, new approaches are required for the effective delivery of DSF to treat cancers. Herein, we prepared DSF loaded soy…
Read More...
Read More...