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Pharmatrans Sanaq
A Biopredictive In Vitro Approach for Assessing Compatibility of a Novel Pediatric Hydrocortisone…
The objective of the present work was to screen whether a novel pediatric hydrocortisone granule formulation can be co-administered with common food matrices and liquids.
Methods
Pediatric hydrocortisone granules were studied using a biopredictive in vitro approach. Experiments included an in situ…
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Scaling up fluidised bed coating of sustained release microparticles at high spray rate using the…
Scaling up fluidised bed coating of microparticles with particle size smaller than 150 µm is a challenge because of the high tendency of particle agglomeration. Consequently, the production yield of coating trials are unsatisfactory and low spray rate is typically applied leading to long duration of…
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Raman Spectroscopy as a PAT-Tool for Film-Coating Processes: In-Line Predictions Using one PLS Model…
Although Raman spectroscopy has been described as a potential process analytical technique for tablet coating, it has rarely been transferred from academic studies to commercial manufacturing applications. The reasons for this are probably not only the high level of process understanding and…
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Introduction of the energy to break an avalanche as a promising parameter for powder flowability…
Dynamic avalanche testing is a newer method useful even with cohesive powder samples. To evaluate flow properties of pharmaceutical powder excipients, break energy (BE) is introduced as a new promising avalanche parameter. Conventional pharmacopoeial methods and an annular shear cell were utilized…
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Regulating the pH of bicarbonate solutions without purging gases: Application to dissolution testing…
Dissolution media based on bicarbonate buffers closely mimic the environment of intestinal fluids and thus improve in vitro in vivo correlation compared to phosphate buffers. Purging gases into the medium is used as a method to stabilise bicarbonate buffers; however, this causes issues due to the…
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Rheological & Suspending Properties of Commonly Used Oral Suspending Vehicles
Little is documented about the rheology of commonly oral used suspending vehicles (which include everything from water through commercial suspending agents to semi-solid foods such as yoghurt which are often used in the administration of medicines to children). Following on from this, little is…
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Easy to Swallow “Instant” Jelly Formulations for Sustained Release Gliclazide Delivery
It is a challenge to safely administer sustained release medicines to patients with dysphagia. Sustained release tablets must not be crushed and multiparticulates with large particle sizes cause gritiness reducing patient acceptability. The aim of this study was to develop “instant” jellies as…
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Assessment of the effect of Cellets’ particle size on the flow in a Wurster fluid-bed coater via…
The main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on the powder properties to assess the possible impact of the Cellets’ size on the powder behaviour in the down-flow bed and horizontal transport zone when a Wurster…
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Fluidized and Spouted Bed for the preparation of directly processable amorphous solid dispersions
One of the major challenges for modern formulation development is the increasing number of poorly water-soluble drugs. A common formulation approach to improve the solubility of those poorly soluble active ingredients is to formulate them as amorphous solid dispersions (ASDs) with a suitable polymer…
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Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and…
A design of experiments (DOE) approach (2-level full factorial design) was used to investigate the effect of several formulation and process variables on the properties of fast disintegrating tablets comprising starch-based pellets and excipient granules and to optimize and validate the design…
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