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PMC Isochem
A Customized Screening Tool Approach for the Development of a Self-Nanoemulsifying Drug Delivery…
The present study focused on establishing a novel, (pre-)screening approach that enables the development of promising performing self-nanoemulsifying drug delivery systems (SNEDDSs) with a limited number of experiments. The strategic approach was based on first identifying appropriate excipients…
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Tocopherols as antioxidants in lipid-based systems: The combination of chemical and physicochemical…
Lipid oxidation is a major concern in the food, cosmetic, and pharmaceutical sectors. The degradation of unsaturated lipids affects the nutritional, physicochemical, and organoleptic properties of products and can lead to off-flavors and to the formation of potentially harmful oxidation compounds.…
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Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid dispersion of baicalein using hot-melt extrusion technology to improve…
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Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA 64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid dispersion of baicalein using hot-melt extrusion technology to…
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Impressions of the Excipients Hall at CPhI 2021
Today is the last day of the CPhI worldwide in Milan 2021. We want to show you the general look and feel with a few walkthroughs and photos.Walkthrough Excipients Hall 7 at CPhI 2021 in Milan
:Walkthrough Hall P-Mec at CPhI 2021 in Milan:
See our interview with beneo at the CPhI 2021…
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Formulation of ternary genistein β-cyclodextrin inclusion complex: In vitro characterization and…
Genistein (GT) is a poorly water-soluble flavonoid and reported for different biological activity. The present work was designed to prepare the inclusion complex using β-Cyclodextrins (β-CDs) as complexing agent and D -α-Tocopherol polyethylene glycol 1000 succinate (TPGS) as ternary substance to…
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Your visit at CPhI worldwide in Milan
CPhI worldwide opens its real doors again after one year of digital trade show! This year in Milan at the Fiera Milano. Next week, from 9th to 11th November, you can finally have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack, P-MEC, FDF, ICSE and BioProduction will be…
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Monosaccharide-induced growth and higher order transitions in TPGS micelles
D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) is a nonionic surfactant with low critical micelle concentration. It usually forms spherical core-shell micelles in aqueous media. In this work, we show that these spherical micelles transform to ellipsoid and cylindrical structures upon…
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Hepatoprotective, antioxidant and anti-inflammatory potentials of Vit-E/C@SeNPs in rats: Synthesis,…
This study aimed to synthesize a nano-structure between selenium, Vit. C, and Vit. E (Vit-E/C@SeNPs) as a promising protective and therapeutic agent for hepatocellular carcinoma. Vit-E/C@SeNPs were characterized using TEM and DLS and its zetapotential was measured to evaluate its stability. DPPH…
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Design of Biopharmaceutical Formulations Accelerated by Machine Learning
In addition to activity, successful biological drugs must exhibit a series of suitable developability properties, which depend on both protein sequence and buffer composition. In the context of this high-dimensional optimization problem, advanced algorithms from the domain of machine learning are…
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