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PMC Isochem
TPGS-Modified Long-Circulating Liposomes Loading Ziyuglycoside I for Enhanced Therapy of…
Background: Ziyuglycoside I (ZgI), an active ingredient isolated from traditional Chinese medicine Sanguisorba officinalis L, has been demonstrated to increase the leucocytes and protect hematopoietic stem cells. However, the poor solubility and a short half-life of ZgI limit its bioavailability and…
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Monitoring the microenvironment inside polymeric micelles using the fluorescence probe…
6-propionyl-2-dimethylaminonaphthalene (PRODAN) is a fluorescent molecule with sensitivity to environmental polarity and hydrogen bond interactions. Although it has been extensively used to study organized systems such as vesicles and reverse micelles, its potential application to characterize…
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Inclusion of Medium-Chain Triglyceride in Lipid-Based Formulation of Cannabidiol Facilitates…
Oral sesame oil-based formulation facilitates the delivery of poorly water-soluble drug cannabidiol (CBD) to the lymphatic system and blood circulation. However, this natural oil-based formulation also leads to considerable variability in absorption of CBD. In this work, the performance of…
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N-trimethyl chitosan coated nano-complexes enhance the oral bioavailability and chemotherapeutic…
N-trimethyl chitosan (TMC) is a multifunctional polymer that can be used in various nanoparticle forms in the pharmaceutical, nutraceutical and biomedical fields. In this study, TMC was used as a mucoadhesive adjuvant to enhance the oral bioavailability and hence antitumor effects of gemcitabine…
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Evaluation of the Antitumor Effect and Immune Response of Micelles Modified with a Polysialic…
D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) has shown potential applications in cancer therapy owing to its attractive properties, including reversal of multi-drug resistance and synergistic effects with antitumor drugs. However, its associated shortcomings cannot be underestimated,…
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Vitamin E-tocopheryl polyethylene glycol succinate decorated drug delivery system with synergistic…
To overcome cancer drug resistance and to reverse tumor immunosuppression, a vitamin E-tocopheryl polyethylene glycol succinate (TPGS) decorated polymer-based drug delivery system was developed. The effects of the drug delivery system on diverse proteins involved in cell apoptosis, cancer invasion,…
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Improved oral bioavailability, cellular uptake and cytotoxic activity of zingerone via nano-micelles…
Herein, a nano-micelle drug delivery system was developed to orally improved zingerone’s bioavailability and its antitumor effect. Indeed, zingerone-loaded D-α-tocopheryl polyethylene glycol succinate micelles (ZTMs) were effectively prepared, characterised and assessed. The ZTMs had diameter,…
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An ultrasonographic assisted investigation for the enhancement of duodenal/cecal motility of…
Gastrointestinal (GI) disorders affect millions of people and are considered a major cause of global morbidity. Mosapride citrate (MOS) is a prokinetic agent with antiemetic effect. The drug suffers from poor bioavailability that is induced by its low solubility. The present study aimed to enhance…
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Development of Gelucire® 48/16 and TPGS Mixed Micelles and Its Pellet Formulation by Extrusion…
The oral bioavailability of curcumin is limited, attributed to its low solubility or dissolution and poor absorption. Herein, the study describes formulation of curcumin-loaded mixed micelles of Gelucire® 48/16 and TPGS for its dissolution rate enhancement. Curcumin was dispersed in these molten…
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Drug crystal growth in ternary amorphous solid dispersions: Effect of surfactants and polymeric…
The present study evaluates the crystal growth rate of amorphous drugs when dispersed in different ternary polymeric amorphous solid dispersions (ASDs) in the presence of surfactants. Specifically, ternary ASDs of aprepitant (APT, selected as a model drug) were prepared via melt-quench cooling by…
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