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PMC Isochem
Nose to brain delivery of tailored clozapine nanosuspension stabilized using (+)-alpha-tocopherol…
Clozapine is widely used to treat schizophrenia as an atypical antipsychotic. Low solubility, poor dissolution rate, degradation in the gastrointestinal tract, high hepatic first-pass metabolism, and eventually less drug transfer in the brain are all issues with oral clozapine administration. On…
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PMC Group International Announces Acquisition of Copperhead Chemical Company
MOUNT LAUREL, N.J.--(BUSINESS WIRE)--PMC Group International, Inc., which is an independent arm of PMC Group Companies, announced the acquisition of Cobra Investments Management Inc. and its two subsidiaries, Copperhead Chemical Company Inc. (“Copperhead”) and Copperhead Investments Inc., from a…
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CDMO for PolyAmino Acids – PMC Isochem
Why a PAA based delivery technology?
Growing interest for advanced biomedicines!
Polyamino acids (PAAs)-based materials have gained much attention in the field of biomedicine as they demonstrate remarkable biocompatibility and biodegradability due to the nature of the building amino acid…
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Generation of Ophthalmic Nanosuspension of Prednisolone Acetate Using a Novel Technology
Purpose
Prednisolone Acetate (PAC) is currently marketed as micronized ophthalmic suspension. The microsuspension has poor dose accuracy and efficacy due to aggregation, slow dissolution rate and limited corneal residence. The ophthalmic nanosuspension of PAC shall show enhanced solubility,…
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Combination of Nanomicellar Technology and In Situ Gelling Polymer as Ocular Drug Delivery System…
A combination of in situ gelling systems and a loaded drug self-assembling nanomicellar carrier was chosen in this study as a new potential Ocular Drug Delivery System (ODDS) for Cyclosporine-A (CyA), a poorly water-soluble drug. Two non-ionic surfactants (d-α-tocopherol polyethylene glycol…
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Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement…
This study aims to examine the contribution of nanoporous silica entrapped lipid-drug complexes (NSCs) in improving the solubility and bioavailability of dutasteride (DUT). An NSC was loaded with DUT (dissolved in lipids) and dispersed at a nanoscale level using an entrapment technique.
NSC…
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Stability properties and antioxidant activity of curcumin nanosuspensions in emulsion systems
In this study, curcumin nanosuspensions (Cur-NSs) were prepared using D-alpha-tocopheryl polyethylene glycol succinate (vitamin E TPGS), and their physical properties (i.e., particle size, dispersion stability) were investigated. Also, the antioxidant activity of Cur-NSs in emulsion systems was…
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Exploring precipitation inhibitors to improve in vivo absorption of cinnarizine from supersaturated…
Supersaturated lipid-based drug delivery systems are increasingly being explored as a bio-enabling formulation approach, particularly in preclinical evaluation of poorly-water soluble drugs. While increasing the drug load through thermally-induced supersaturation resulted in enhanced in vivo…
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Advancement on Sustained Antiviral Ocular Drug Delivery for Herpes Simplex Virus Keratitis: Recent…
The eyes are the window to the world and the key to communication, but they are vulnerable to multitudes of ailments. More serious than is thought, corneal infection by herpes simplex viruses (HSVs) is a prevalent yet silent cause of blindness in both the paediatric and adult population, especially…
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PMC Isochem To accelerate Polyamino acids Business as part of ISODEL® Drug Delivery offer, a unique…
Press release - Contact: Patti Griggs 856-533-1870
PMC Isochem announces today that it is accelerating the strategic development and manufacture of polyamino acids (PAA) as functional excipients used in complex formulations and drug delivery solutions. Based on its own internal resources and…
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