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PMC Isochem
Poloxamine/D-α-Tocopheryl polyethylene glycol succinate (TPGS) mixed micelles and gels: Morphology,…
The combination of polymeric surfactants with different features into mixed micelles give access to properties that may be superior to the single-component micelles. In this work, we investigated synergistic effects in mixtures of D-α-Tocopheryl polyethylene glycol succinate (TPGS) with poloxamines…
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Nanocarriers based on vitamin E-TPGS: Design principle and molecular insights into improving the…
α-Tocopheryl polyethylene glycol succinate (Vitamin E-TPGS or TPGS) is a nonionic amphiphile synthesized by the esterification of vitamin E succinate. It has been categorized as a safe excipient by US-FDA and EMA. Like other polyethylene glycol (PEG) condensates, TPGS spontaneously forms kinetically…
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Paclitaxel-Loaded Colloidal Silica and TPGS-Based Solid Self-Emulsifying System Interferes Akt/mTOR…
A solid self-emulsifying drug delivery system (SEDDS) of paclitaxel (PTX) was developed that could enhance its oral bioavailability and neutralize other niggles associated with conventional delivery systems of PTX. TPGS-centered SEDDS containing PTX was optimized by Box-Behnken experimental design…
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Liquisolid tablets – A rationale for formulation and process design
A significant proportion of new API’s in development are poorly soluble and require alternative formulation approaches to achieve adequate oral bioavailability. One option is to develop lipid-based formulations. Lipid formulations are typically liquids but can be converted into solid dosage forms…
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Development and optimization of vitamin E TPGS based PLGA nanoparticles for improved and safe ocular…
Topical ocular delivery of therapeutics are always a challenging arena in order to achieve high ocular bioavailability with safe administration. Ideal ocular delivery of drug required 4 P's that is Patient compliance, Prolong retention, Penetration to cornea and Prolong release of drug. In an…
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Enhanced oral bioavailability of self-Assembling curcumin-vitamin E prodrug-nanoparticles by…
Curcumin (CUR), a non-toxic natural compound with potent antitumor activity, was limited in clinical application due to its insolubility and exceedingly low bioavailability. In this study, a novel prodrug-nanoparticles (CSSV/TPGS-NPs) self-assembled by co-nanoprecipitation of curcumin-s-s-vitamin E…
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Role of the Encapsulation in Bioavailability of Phenolic Compounds
Plant-derived phenolic compounds have multiple positive health effects for humans attributed to their antioxidative, anti-inflammatory, and antitumor properties, etc. These effects strongly depend on their bioavailability in the organism. Bioaccessibility, and consequently bioavailability of…
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New pharmaceutical dosage forms used in the treatment of breast cancer. Polymeric micelles
Among all types of cancer encountered in women, breast cancer is the most prevalent, with the highest mortality rate. An increased survival rate is closely related to early diagnosis, the use of high performing screening methods and of selective and adequate treatments. By using the…
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Synergistic and antagonistic effects of non-ionic surfactants with bile salt + phospholipid mixed…
The nature of the interaction of bile salt micelles with exogenous surfactants used in formulations and the consequent impact on drug solubilisation is not well understood. It is often assumed that addition of any surfactant will lead to an enhanced solubility of drug, which is often true in water…
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Rebaudioside A/TPGS mixed nanomicelles as promising nanocarriers for nimodipine ocular delivery
Nimodipine (NMD), a calcium channel blocker, has demonstrated benefits in treating glaucoma. However, its ocular therapeutic application remains limited due to its poor aqueous solubility, which restrains the development of an ophthalmic formulation. Thus, the present study aimed to formulate an NMD…
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