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PMC Isochem
Design and Characterization of Cyclosporine A-Loaded Nanofibers for Enhanced Drug Dissolution
Despite widespread use as an immunosuppressant, the therapeutic efficacy of the undecapeptide cyclosporine A (CyA) is compromised when given by the oral route because of the innate hydrophobicity of the drug molecule, potentially leading to poor aqueous solubility and bioavailability.
The aim of…
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Formulation of Ketoconazole Nanocrystal-Based Cryopellets
Commercial development of nanosuspensions for oral drug delivery generally involves a drying step which aims to generate a stable product that rapidly releases the nanocrystals once rehydrated and can be easily processed into a final dosage form (e.g., filled into hard capsule).
Cryopelletisation…
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Vitamin E TPGS based transferosomes augmented TAT as a promising delivery system for improved…
Raloxifene is commonly used for breast cancer protection. The low bioavailability of raloxifene (2%) is the result of its low solubility and intestinal glucuronidation.
The nano-lipid carriers are characterized by small particle size, biocompatibility, and sustainable properties that improve…
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Design space approach in the development of esculetin nanocrystals by a small-scale wet-bead milling…
Esculetin, a natural coumarin derived from herbs, has shown different potential pharmacological activities. However, the poor aqueous solubility of esculetin may limit its therapeutic efficacy. Nanocrystal is a promising dosage form to overcome this drawback by enhancing drug saturation solubility.…
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Scale-up of electrospinning technology: Applications in the pharmaceutical industry
Electrospinning (ES) was originally reported in 1899 and the technology has been used since for the fabrication of con- tinuous fibers (Cooley, 1899).
Beginning from the 1980s and particularly during the recent decade, the technology has gained increasing attention. Possibly this can be…
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Ameliorated in vitro anticancer efficacy of methotrexate D-α-Tocopheryl polyethylene glycol 1000…
Background
Methotrexate (MTX), a folate anti-metabolite, has been used widely in the treatment of plenty of malignancies. However, the clinical use is limited because of its poor water solubility (BCS class II drug), nonspecific distribution, drug resistance, short circulation half-life, and…
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In vitro and in vivo cardioprotective and metabolic efficacy of vitamin E TPGS/Apelin
Aims
Apelin and vitamin E have been proposed as signaling molecules, but their synergistic role is unknown. The aim of this work was to develop vitamin E TPGS/Apelin system to test their cardioprotective and metabolic efficacy in vitro and in vivo.
Methods
FDA-approved surfactant…
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Solid lipid nanoparticles and nanostructured lipid carriers in oral cancer drug delivery
Most cancer disease can be treated by the parenteral anticancer delivery method. The intravenous route takes the wholly bioavailable, accurate dose of the drug immediately to the body, but high plasma concentration has some side effects.
Furthermore, i.v. chemotherapy is painful and may cause…
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Carvedilol solid dispersion for enhanced oral bioavailability using rat model
The objective of the present study was to develop a solid dispersion formulation to improve oral bioavailability of poorly water-soluble drug carvedilol. Several solid dispersions were prepared by fusion-solvent method mixing different concentrations of Gelucire 44/14 and Gelucire 50/13. To the…
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Successful development of oral SEDDS: screening of excipients from the industrial point of view
Oral administration is the most accepted and favored route as various side effects such as fear, pain and risk of infections can be avoided resulting in a comparatively high patient compliance.
However, from the industrial point of view the development of oral delivery systems is still…
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