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PMC Isochem
Chitosan film of thiolated TPGS-modified Au-Ag nanoparticles for combating multidrug-resistant…
The widely used vitamin-E based amphiphilic material, tocopheryl polyethylene glycol succinate (TPGS) is further improvised as redox-sensitive thiolated TPGS (TPGS-SH), which has been developed by attaching 4-aminothiophenol. Further, TPGS and TPGS-SH-coated bimetallic gold-silver nanoparticles…
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Multicompartmental pharmacokinetic evaluation of enavogliflozin eye drop formulation: Understanding…
Abstract
Purpose
Treating posterior segment diseases presents significant challenges because of the intricate anatomical and physiological barriers within the eye that limit drug penetration. Enavogliflozin eye drops (DWRX2008) are a novel candidate for diabetic retinopathy; however, their…
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TPGS/soluplus® blended micelles: an effective strategy for improving loading capacity of ferroptosis…
Erastin is the most classical small molecular ferroptosis inducer but its clinical application is hindered due to its poor solubility. Nanotechnology has been used to improve ferroptosis inducer erastin’s solubility. The recently reported erastin-incorporated nanosystems (e.g., nanoparticulate…
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Cyclosporine A micellar nasal spray characterization and antiviral action against SARS-CoV-2
The upper airways represent the point of entrance from where Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection spreads to the lungs. In the present work, α-tocopheryl-polyethylene-glycol succinate (TPGS) micelles loaded with cyclosporine A (CSA) were developed for nasal…
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Engineering a novel water-in-oil biocompatible microemulsion system for the ocular delivery of…
Due to their unique characteristics, microemulsions (ME) represent one of the most promising delivery systems which can conquer poor ocular drug bioavailability providing long residence time. Development of a ME system, relying on the use of a safe and non-irritant surfactant combination derived…
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The Development of Lipid-Based Sorafenib Granules to Enhance the Oral Absorption of Sorafenib
Abstract
Sorafenib (SFN) is an anticancer multi-kinase inhibitor with great therapeutic potential. However, SFN has low aqueous solubility, which limits its oral absorption. Lipids and surfactants have the potential to improve the solubility of water-insoluble drugs. The aim of this study is thus…
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Development of a novel squalene/a-tocopherol-based self-emulsified nanoemulsion incorporating…
Abstract
Vaccination has emerged as the most effective strategy to confront infectious diseases, among which is leishmaniasis, that threat public health. Despite laborious efforts there is still no vaccine for humans to confront leishmaniasis. Multi-epitope protein/peptide vaccines present a number…
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Nanostructured Lipid Carriers for Improved Delivery of Therapeutics via the Oral Route
Abstract
Drug delivery via the oral route has always been challenging for poorly soluble drugs. Acid-induced hydrolysis, enzymatic degradation, and poor mucosal absorbency remain the primary hiccups for effective oral delivery of medications. With the advent of nanotechnology, nanostructured lipid…
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Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs
Abstract
The pharmaceutical sector has made considerable strides recently, emphasizing improving drug delivery methods to increase the bioavailability of various drugs. When used as a medication delivery method, nanoemulsions have multiple benefits. Their small droplet size, which is generally…
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Design of Redispersible High-Drug-Load Amorphous Formulations: Impact of Ionic vs Nonionic…
Amorphous solid dispersions (ASDs) are an enabling formulation approach used to enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich amorphous nanoparticles generated in situ during ASD dissolution maintain supersaturation that drives enhanced absorption.…
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