Browsing Category
PMC Isochem
Development and evaluation of niacinamide transdermal formulation by artificial membrane…
Despite many efforts to improve the transdermal permeability of drugs, most of them are blocked by the skin barrier. Niacinamide (NAC) is a Biopharmaceutics Classification System class I drug with high aqueous solubility and intestinal permeability. Due to the high solubility and intestinal…
Read More...
Read More...
Size-optimized simvastatin TPGS modified lipid nanocapsules for targeting epithelial-to-mesenchymal…
ABSTRACT
Objectives
Novel D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) modified lipid nanocapsules (LNC) were prepared with the aim of improving the effectiveness of simvastatin (SIM) in hepatocellular carcinoma (HCC). The present study, therefore, sought to investigate the…
Read More...
Read More...
Transferrin functionalized nanostructured lipid carriers for targeting Rivastigmine and Resveratrol…
The management of Alzheimer's disease (AD) remains challenging owing to its complex pathophysiology and blood-brain barrier (BBB) restrictions. A rationally designed combination drug multi-target strategy has emerged as a promising approach for AD management. Considering the lipophilic nature of BBB…
Read More...
Read More...
Experimental Design of D-α-tocopherol polyethylene glycol 1000 succinate Stabilized Bile Salt Based…
Nowadays, conventional anticancer therapy suffers many pitfalls, including drastic side effects and limited therapeutic efficacy resulting from diminished oral bioavailability. So, in an attempt to enhance their poor solubility and oral bioavailability along with the cytotoxic activity, the…
Read More...
Read More...
Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for…
HIV/AIDS remains a major global public health issue. While antiretroviral therapy is effective at reducing the viral load in the blood, up to 50% of those with HIV suffer from some degree of HIV-associated neurocognitive disorder, due to the presence of the blood-brain barrier restricting drugs from…
Read More...
Read More...
Nanostructured Lipid Carrier Co-Loaded with Docetaxel and Magnetic Nanoparticles: Physicochemical…
Lung cancer is currently the most prevalent cause of cancer mortality due to late diagnosis and lack of curative therapies. Docetaxel (Dtx) is clinically proven as effective, but poor aqueous solubility and non-selective cytotoxicity limit its therapeutic efficacy. In this work, a nanostructured…
Read More...
Read More...
PVP solid dispersions containing Poloxamer 407 or TPGS for the improvement of ursolic acid release
Solid dispersions (SDs) of ursolic acid (UA) were developed using polyvinylpyrrolidone K30 (PVP K30) in combination with non-ionic surfactants, such as D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) or poloxamer 407 (P407) with the aim of enhancing solubility and in vitro release of the…
Read More...
Read More...
Unraveling the pharmaceutical and clinical relevance of the influence of syringic acid loaded…
Natural medicines are promising platforms for competent topical treatment modalities benefiting the cosmetic implementation and proffering solutions to the current remedies. Therefore, the objective of this study was to formulate syringic acid (SA), well-known for its multilateral anti-inflammatory,…
Read More...
Read More...
Solubility improvement of curcumin by crystallization inhibition from polymeric surfactants in…
To improve the solubility and maintain the amorphous state of BCS Ⅳ drug by preparing surfactant solid dispersions, solid dispersions of curcumin (CUR) with TPGS and HPMC were prepared by solvent method. The synthesized solid dispersions were characterized by scanning electron microscopy, powder…
Read More...
Read More...
Vitamin E TPGS-Based Nanomedicine, Nanotheranostics, and Targeted Drug Delivery: Past, Present, and…
It has been seventy years since a water-soluble version of vitamin E called tocophersolan (also known as TPGS) was produced; it was approved by USFDA in 1998 as an inactive ingredient. Drug formulation developers were initially intrigued by its surfactant qualities, and gradually it made its way…
Read More...
Read More...