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Roquette
Lutein Loaded in β-Cyclodextrin Metal-Organic Frameworks for Stability and Solubility Enhancements
Lutein (Lut) is a recognized nutritional supplement known for its antioxidative and anti-inflammatory properties, crucial in mitigating ocular disease. However, enhancements to Lut stability and solubility remain challenges to be addressed in the healthcare industry. Herein, we fabricated and…
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A modified mechanistic approach for predicting ribbon solid fraction at different roller compaction…
Abstract
This research investigates the modeling of the pharmaceutical roller compaction process, focusing on the application of the Johanson model and the impact of varying roll speeds from 1 to 15 RPM on predictive accuracy of ribbon solid fraction. The classical Johanson’s model was integrated…
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An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of…
Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate. However, most new chemical entities exhibit poor water solubility, and hence are exempt from such benefits. Although combining drug amorphization with…
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The development of an innovative method to improve the dissolution performance of rivaroxaban
Abstract
Recent advancements in the formulation of solid dosage forms involving active ingredient-cyclodextrin complexes have garnered considerable attention in pharmaceutical research. While previous studies predominantly focused on incorporating these complexes into solid states, issues…
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Using Βeta-cyclodextrin and Plasdone K-30 Polymers for Enhancing Drug Solubility by Spray Drying
Abstract
The purpose of this study was to investigate improving solubility using hydrophilic/water-soluble polymers as β-Cyclodextrin and Plasdone K-30 in a solid dispersion formulation of Carvedilol a poorly soluble drug. The developed solid dispersion consisted of two components, a drug…
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Towards the Development of a Cream with Antiviral Properties Targeting Both the Influenza A Virus…
Abstract
Objective: Many severe acute respiratory infections are caused by viral pathogens, and viruses are responsible for a large number of deaths worldwide. Among the most common respiratory viruses are the influenza A virus (IAV) and, more recently, the SARS-CoV-2 that emerged in 2019 and…
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Designing starch-based fenofibrate formulations using the melting method
Fenofibrate (FNF) is used to treat hyperlipidemia. However, FNF is a poorly water-soluble drug, and the dosage of commercial products is relatively high at 160 mg in a Lipidil® tablet. Therefore, this study aimed to develop an FNF-solid dispersion (SD) that solubilizes and stabilizes FNF. The…
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Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms
ABSTRACT
This comprehensive review explores modern granulation techniques in pharmaceutical dosage forms along with conventional methods, focusing on dry granulation and wet granulation. Dry granulation techniques, including slugging, roller compaction, and pneumatic dry granulation, are…
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Specific surface area of mannitol rather than particle size dominant the dissolution rate of poorly…
The dissolution behavior of tablets, particularly those containing poorly water-soluble drugs, is a critical factor in determining their absorption and therapeutic efficacy. Traditionally, the particle size of excipients has been considered a key property affecting tablet dissolution. However,…
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Evaluating Solubility, Stability, and Inclusion Complexation of Oxyresveratrol with Various…
Oxyresveratrol (OXY), a natural stilbenoid in mulberry fruits, is known for its diverse pharmacological properties. However, its clinical use is hindered by low water solubility and limited bioavailability. In the present study, the inclusion complexes of OXY with β-cyclodextrin (βCD) and its three…
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