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Roquette
Effects of Granulated Lactose Characteristics and Lubricant Blending Conditions on Tablet Physical…
Abstract
Lactose is an excipient used extensively for bulking, diluting, and molding active pharmaceutical ingredients in tablet manufacturing. Particularly, granulated lactose (GL) intended for direct powder compression has distinct properties due to differences in manufacturing methods. It…
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Optimization of ultra-sonicated homogenization conditions of fish oil emulsions to improve…
This study aimed to improve the quality characteristics of fish oil microcapsules from monolayer and multilayer emulsions by optimizing the ultra-sonicated homogenization conditions to obtain a stable source of omega-3 fatty acids to add in food matrix. For that, a response surface methodology trial…
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A starch-based implant as a controlled drug release system: Non-invasive in vivo characterization…
Solid implants are parenteral depot systems that can provide a controlled release of drugs in the desired body area over a few days to months. Finding an alternative for the two most commonly used polymers in the production of parenteral depot systems, namely Poly-(lactic acid) (PLA) and…
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The relationship between molecular-structural properties and functional-related characteristics of…
Croscarmellose sodium (CCS)is a superdisintegrant used in the formulation of pharmaceutical tablets. As with most other pharmaceutical ingredients, CCS is produced by various manufacturers. Our previous work has shown that products of different manufacturers can have varying properties and…
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Wet granulation of co-amorphous indomethacin systems
The feasibility of co-amorphous systems to be wet granulated together with microcrystalline cellulose (MCC) was investigated. Solid state and molecular interactions were analysed for various co-amorphous drug-amino acid formulations of indomethacin with tryptophan and arginine, respectively, via…
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Inhalation powder development without carrier: How to engineer ultra-flying microparticles?
Particle engineering technologies have led to the commercialization of new inhaled powders like PulmoSolTM or PulmoSphereTM. Such platforms are produced by spray drying, a well-known process popular for its versatility, thanks to wide-ranging working parameters. Whereas these powders contain a high…
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Investigation on nozzle zone agglomeration during spray drying using response surface methodology
During spray drying, dry powder is circulated into the nozzle zone to force collisions, inducing agglomeration. This study systematically determined the effect of fine powder mass flowrate (varying from 7.1 ± 1.2–15.9 ± 0.5 kg∙h−1), drying air temperature (160–200 °C), and drying air mass flowrate…
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In-line particle size measurement during granule fluidization using convolutional neural…
This paper presents a machine learning-based image analysis method to monitor the particle size distribution of fluidized granules. The key components of the direct imaging system are a rigid fiber-optic endoscope, a light source and a high-speed camera, which allow for real-time monitoring of the…
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In Vitro and In Vivo Evaluation of Composite Oral Fast Disintegrating Film: An Innovative Strategy…
Here, we evaluate the feasibility of co-loading plain ranitidine hydrochloride (RHCl) and microencapsulated flurbiprofen (FBP) in a Lycoat® RS780-based oral fast disintegrating film (ODF). These films were developed by the solvent casting method to minimize the adverse effects of FBP and reduce the…
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Dynamic investigation of maltodextrins surface properties by environmental atomic force microscopy
Abstract
For the first time on food powders, environmental Atomic Force Microscopy (AFM) was used to probe single particle surface properties in real time by variating relative humidity (RH) and temperature. Low, intermediate, and high dextrose equivalent (DE) maltodextrins values were used as a…
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