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Roquette
Roquette Cuts Ribbon on $25 Million Pharmaceutical Innovation Center in the United States
PRESS RELEASE
La Madeleine, France, and Philadelphia, USA – April 19, 2023. Roquette, a global leader in plant-based ingredients and a leading provider of pharmaceutical and nutraceutical excipients, today celebrates the grand opening of its new Pharmaceutical Innovation Center, located near…
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Development of Clinically Optimized Sitagliptin and Dapagliflozin Complex Tablets: Pre-Formulation,…
The purpose of this study is to derive an optimal drug release formulation with human clinical bioequivalence in developing a sitagliptin phosphate monohydrate-dapagliflozin propanediol hydrate fixed-dose combination (FDC) tablet as a treatment for type 2 diabetes mellitus. As a treatment for type 2…
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Development and Characterization of the Floating Beads Containing the BCS Class II Drug Lumafentrine…
Floating Drug delivery systems are designed to prolong the gastric residence time after oral administration. Gastroretentive systems can remain in the gastric region for several hours and significantly prolong the gastric residence of the drugs. Prolonged gastric retention improves bioavailability,…
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High-Speed Tableting of High Drug-Loaded Tablets Prepared from Fluid-Bed Granulated Isoniazid
The aim of this feasibility study was to investigate the possibility of producing industrial-scale relevant, robust, high drug-loaded (90.9%, w/w) 100 mg dose immediate-release tablets of isoniazid and simultaneously meet the biowaiver requirements. With an understanding of the real-life…
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Impact of matrices composition and processes on β-galactosidase encapsulation
Advances in existing drying techniques are essential for upgrading large scale industries. Enzymes are often degraded by drying processes. Spray drying (SD) has detrimental effects on bioactive molecules at high temperatures. Freeze-drying (FD) is a reference technique capable of drying sensible…
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In Vitro and In Vivo Characterization of the Transdermal Gel Formulation of Desloratadine for…
Chronic use of antihistamines can induce abnormalities in lipid absorption with potential excessive accumulation of lipids in the mesentery that can lead to the development of obesity and a metabolic syndrome. The focus of the present work was to develop a transdermal gel formulation of…
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Impact of Different Saccharides on the In-Process Stability of a Protein Drug During Evaporative…
Objectives
Solid biopharmaceutical products can circumvent lower temperature storage and transport and increase remote access with lower carbon emissions and energy consumption. Saccharides are known stabilizers in a solid protein produced via lyophilization and spray drying (SD). Thus, it is…
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Discrimination of β-cyclodextrin/hazelnut (Corylus avellana L.) oil/flavonoid glycoside and…
The goal of the study was the discrimination of β-cyclodextrin (β-CD)/hazelnut (Corylus avellana L.) oil/antioxidant ternary complexes through Fourier-transform infrared spectroscopy coupled with principal component analysis (FTIR–PCA). These innovative complexes combine the characteristics of the…
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Assessment of Tribo-charging and Continuous Feeding Performance of Direct Compression Grades of…
Tribo-charging is often a root cause of mass flow deviations and powder adhesion during continuous feeding. Thus, it may critically impact product quality. In this study, we characterized the volumetric (split- and pre-blend) feeding behavior and process-induced charge of two direct compression…
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Impact of Tablet Size and Shape on the Swallowability in Older Adults
Older adults represent the major target population for oral medications, due to the high prevalence of multimorbidity. To allow for successful pharmacological treatments, patients need to adhere to their medication and, thus, patient-centric drug products with a high level of acceptability by the…
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