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Roquette
Injectable Chitosan-Based Hydrogels for Trans-Cinnamaldehyde Delivery in the Treatment of Diabetic…
Diabetic foot ulcers (DFU) are among the most common complications in diabetic patients and affect 6.8% of people worldwide. Challenges in the management of this disease are decreased blood diffusion, sclerotic tissues, infection, and antibiotic resistance. Hydrogels are now being used as a new…
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Oral lyophilizates obtained using aggressive drying conditions: Effect of excipients
Orodispersible drug formulations are a current trend in the pharmaceutical industry, mostly intended for pediatric and geriatric patients. Oral lyophilizates are solid forms, intended either to be placed in the mouth or to be dispersed (or dissolved) in water before administration. The correct…
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Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets…
A majority of therapeutics are not available as suitable dosage forms for administration to pediatric patients. The first part of this review provides an overview of clinical and technological challenges and opportunities in the development of child-friendly dosage forms such as taste masking,…
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Co-processed Hydroxypropyl Methylcellulose – Mannitol as a Directly Compressible Excipient for…
Introduction
Controlled release dosage forms deliver an effective dose of the active pharmaceutical ingredient over a prolonged duration, which is particularly advantageous to maintain a constant plasma drug concentration within the therapeutic window. This effectively overcomes the negative…
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Insight into the mechanism behind oral bioavailability-enhancement by nanosuspensions through…
As numerous new drug candidates are poorly water soluble, enabling formulations are needed to increase their bioavailability for oral administration. Nanoparticles are a conceptually simple, yet resource consuming strategy for increasing drug dissolution rate, as predicting in vivo oral absorption…
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PEARLITOL® 200 GT Mannitol by Roquette
Speed. Precision. Patient-centricity.
Roquette´s PEARLITOL® 200 GT granulated mannitol is here to revolutionize direct compression. Realize the potential of novel drug formats with smaller, harder tablets produced at unprecedented speeds – without compromising on quality.
PEARLITOL® 200 GT…
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Preparation and evaluation of astaxanthin-loaded 2-hydroxypropyl-beta-cyclodextrin and Soluplus®…
Abstract
Background
Astaxanthin is a type of food-derived active ingredient with antioxidant, antidiabetic and non-toxicity functions, but its poor solubility and low bioavailability hinder further application in food industry. In the present study, through inclusion technologies, micellar…
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Development and Optimization of Sildenafil Orodispersible Mini-Tablets (ODMTs) for Treatment of…
The availability of age-appropriate oral dosage forms for pediatric patients has remained a challenge. Orodispersible mini-tablets (ODMTs) are a promising delivery system for pediatric patients. The purpose of this work was the development and optimization of sildenafil ODMTs as a new dosage form…
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PEARLITOL® CR-H by Roquette
SEE PEARLITOL® CR-H
Roquette´s new, industry-first mannitol and hydroxypropyl methylcellulose (HPMC) blend, designed for controlled release drug formulation. Leave behind wet granulation, lengthy drying times and limited flowability and unlock the potential of direct compression to create…
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Hydrogel-forming microarray patch mediated transdermal delivery of tetracycline hydrochloride
Antibiotic resistance is one of the most serious health problems today and is expected to worsen in the coming decades. It has been suggested that antibiotic administration routes that bypass the human gut could potentially tackle this problem. In this work, an antibiotic hydrogel-forming microarray…
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