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Roquette
Study of the dextrose equivalent of maltodextrins in electrospinning using an ethanol/water mixture…
Maltodextrin (MD) is a natural polymer ideal for electrospinning due to its non-toxicity, water solubility, and low viscosity. In this investigation, MD solutions, each containing a different dextrose equivalent (DE) value of 18, 10, and 4, were studied in an ethanol/water solvent system for the…
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Randomized clinical study of injectable dextrin-based hydrogel as a carrier of a synthetic bone…
Abstract
Objectives
This study aimed to improve the performance and mode of administration of a glass-reinforced hydroxyapatite synthetic bone substitute, Bonelike by Biosckin® (BL®), by association with a dextrin-based hydrogel, DEXGEL, to achieve an injectable and moldable device named DEXGEL…
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Advanced image analytics to study powder mixing in a novel laboratory scale agitated filter dryer
Powder mixing unit operations are essential to the manufacturing of pharmaceutical drug substance and drug products. To model powder mixing, computational approaches have been used to evaluate mixing indices for different types of mixers, while also necessitating experimental methods for tracking of…
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Celecoxib Nanoformulations with Enhanced Solubility, Dissolution Rate, and Oral Bioavailability:…
Celecoxib (CXB) is a Biopharmaceutical Classification System (BCS) Class II molecule with high permeability that is practically insoluble in water. Because of the poor water solubility, there is a wide range of absorption and limited bioavailability following oral administration. These unfavorable…
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Upscaling of external lubrication from a compaction simulator to a rotary tablet press
External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with automated external lubrication systems implemented in a compaction…
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COMBILOSE: A novel lactose-based co-processed excipient for direct compression
Lactose is the commonly used diluent in the manufacturing of tablets dosage form. However, the poor flowability and compressibility of lactose limit its use as a directly compressible filler binder. In this research work, composite excipient COMBILOSE was developed as a directly compressible filler…
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Formulation and Characterisation of Carbamazepine Orodispersible 3D-Printed Mini-Tablets for…
Abstract
One of the main challenges to paediatric drug administration is swallowing difficulties, hindering the acceptability of the medicine and hence clinical outcomes. This study aims at developing a child-appropriate dosage form, the orodispersible mini-tablet (ODMT), using the model drug…
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Temperature Cycling-Induced Formation of Crystalline Coatings
The surface of particles is the hotspot of interaction with their environment and is therefore a major target for particle engineering. Particles with tailored coatings are greatly desired for a range of different applications. Amorphous coatings applied via film coating or microencapsulation have…
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Formulation-dependent stability mechanisms affecting dissolution performance of directly compressed…
During drug product development, stability studies are used to ensure that the safety and efficacy of a product are not affected during storage. Any change in the dissolution performance of a product must be investigated, as this may indicate a change in the bioavailability. In this study, three…
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Relative Humidity Cycling: Implications on the Stability of Moisture-Sensitive Drugs in Solid…
The stability of a moisture-sensitive drug in tablet formulations depends particularly on the environment’s relative humidity (RH) and the products’ prior exposure to moisture. This study was designed to understand drug stability in relation to the moisture interaction of the excipients, moisture…
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