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Roquette
Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible controlled…
One of the most common forms of controlled release technology for oral drug delivery comprises an active ingredient dispersed in a hydrophilic matrix forming polymer such as hydroxypropyl methylcellulose (HPMC), which is tableted via direct compression. However, HPMC may pose problems in direct…
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Long-acting transdermal drug delivery formulations: Current developments and innovative…
Transdermal administration remains an active research and development area as an alternative route for long-acting drug delivery. It avoids major drawbacks of conventional oral (gastrointestinal side effects, low drug bioavailability, and need for multiple dosing) or parenteral routes (invasiveness,…
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The effect of glidant on the tabletting behavior of common pharmaceutical excipients
Abstract
Glidant used for the purpose of powder flowability enhancement is well known within the pharmaceutical industry to improve tablet manufacturing. Despite the widespread use of glidant for this purpose, the effect of glidant on the effect of tableting behavior is not well studied. To address…
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Studies on enhancement of solubility and dissolution properties of Nimodipine by solid dispersion…
Nimodipine, a member of calcium channel blocker, specifically binds to L-type voltage-gated calcium channels. The maximum solubility of nimodipine was found at pH 1.2 and solubility decreases up to pH 4.0. At a pH 6.0 and higher pH, solubility reduces drastically. Suitable solid dispersion systems…
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Pre-Formulation, Formulation and Pilot Scale-Up Studies to Establish the Qualitative and…
The present study aimed to establish the theoretical qualitative and quantitative formula of a nanoparticle-based dietary supplement suitable for menopause therapy by integrating various herbal active ingredients – e.g. diosgenin – into a nano lipid matrix with vegetable oils. NLCs (nanostructured…
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Prolongation of the gastric residence time of caffeine after administration in fed state: Comparison…
Abstract
The aim of the present study was to investigate the gastroretentive capacity of different formulation principles. This was indirectly determined by the absorption behavior of caffeine from the dosage forms. A slow and continuous appearance of caffeine in the saliva of healthy volunteers…
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Design and development of a chitosan-based nasal powder of dimethyl fumarate-cyclodextrin binary…
The nasal administration route has been studied for the delivery of active molecules directed to the Central Nervous System, thanks to the anatomical connection between the nasal cavity and the brain.
Dimethyl fumarate is used to treat relapsing-remitting multiple sclerosis, with a role as an…
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Opportunities and Challenges: Process Raman for the Real-Time Release Testing (RTRT) of…
Abstract
The use of a process analytical technology has been demonstrated using near-infrared spectroscopy for continuous manufacturing of pharmaceutical formulations and is within the scope of the U.S. Food and Drug Administration's real-time release testing initiative. While effective for simple…
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Enabling Stable and Directly Compressible Probiotic Tablet Formulations with a Novel Co-processed…
This case study was presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
The growing interest in probiotic supplements is driven by the favorable effects on intestinal microbiota and contributions to…
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A comprehensive assessment of machine learning algorithms for enhanced characterization and…
Orodispersible films (ODFs) have emerged as innovative pharmaceutical dosage forms, offering patient-specific treatment through adjustable dosing and the combination of diverse active ingredients. This expanding field generates vast datasets, requiring advanced analytical techniques for deeper…
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