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Roquette
Soft sensor for content prediction in an integrated continuous pharmaceutical formulation line based…
In this study, a concentration predicting soft sensor was achieved based on the Residence Time Distribution (RTD) of an integrated, three-step pharmaceutical formulation line. The RTD was investigated with color-based tracer experiments using image analysis. Twin-screw wet granulation (TSWG) was…
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Hydrogel-forming microarray patches with cyclodextrin drug reservoirs for long-acting delivery of…
Hydrogel-forming microarray patches (HF-MAPs) offer minimally invasive, pain-free and prolonged drug delivery. These devices are designed to be self-administered and self-disabling, avoiding contaminated sharps waste generation. Cabotegravir sodium (CAB-Na) is a poorly soluble anti-human…
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Development of Nafamostat Mesylate Immediate-Release Tablet by Drug Repositioning Using…
We aimed to develop nafamostat mesylate immediate-release tablets for the treatment of COVID-19 through drug repositioning studies of nafamostat mesylate injection. Nafamostat mesylate is a serine protease inhibitor known to inhibit the activity of the transmembrane protease, serine 2 enzyme that…
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Identification of Critical Factors Influencing the In-Vitro Dissolution of Bicalutamide Tablets…
This study was aimed to utilize the Moisture Activated Dry Granulation (MADG) technique to formulate Bicalutamide tablet and identify critical factors influencing its dissolution. The Bicalutamide inclusion complex was formed using the kneading method. Aeroperl 300 was selected as an adsorbent,…
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Pregelatinized Starch as a Binder in Wet Granulation: Optimization of the Incorporation Rate –…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients…
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Controlled release starch-lipid implant for the therapy of severe malaria
Parenteral depot systems can provide a constant release of drugs over a few days to months. Poly-(lactic acid) (PLA) and Poly-(lactide-co-glycolide) (PLGA) are the most commonly used polymers in the production of these systems. Finding alternatives to these polymers is of great importance to avoid…
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Brain uptake and distribution patterns of 2-hydroxypropyl-ß-cyclodextrin after intrathecal and…
Objectives
Cyclodextrins are increasingly used therapeutically. For example, 2-hydroxypropyl-ß-cyclodextrin (kleptose) is used for the treatment of Niemann–Pick disease. Kleptose crosses the blood–brain barrier poorly, in part because of a central nervous system (CNS)-to-blood (efflux)…
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Super-swelling Hydrogel-forming Microneedle based Transdermal Drug Delivery: Mathematical Modelling,…
Super-swelling hydrogel-forming microneedles (HFMNs) based transdermal drug delivery (TDD) is gaining significant interest due to their non-invasiveness and ability to deliver a wide range of drugs. The HFMNs swell by imbibing interstitial skin fluid (ISF), and they facilitate drug transport from…
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Prototypes of Nutraceutical Products From Microparticles Loaded With Stilbenes Extracted From Grape…
Grape canes (Vitis vinifera L.) are an important source of bioactive stilbenes, but they are considered a pruning residue. Despite the potential advantages for human health, the low aqueous solubility and stability limits their usage in commercial goods.
This research aimed to improve knowledge…
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Hydration and dehydration induced changes in porosity of starch microspheres
Characterization and tuning of the porosity of amorphous starch materials are important for many applications, including controlled release of encapsulated proteins. The porosities of these materials in dry and hydrated states can have different physicochemical origins and properties. Here,…
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