Roquette

Aim: The study involved the development and optimization of the fast-dissolving oral films of salbutamol sulfate using high-amylose maize starch (HAMS) as a novel film former by comparison with the HPMC E50 (hydroxy propyl methyl cellulose) films. The high aqueous solubility, low dose, and low…
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The synergistic therapeutic benefits of resveratrol (RES) and piperine (PIP) have been proven for the treatment of various diseases. This study reports, for the first time, spray-drying of hydroxypropyl β-cyclodextrin (HP-β-CD) microcapsules for combined delivery of resveratrol and piperine. Phase…
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Roquette’s plant-based softgel offering is expanding to provide manufacturers with a complete ready-to-use LYCAGEL® Premix. Easy to incorporate into existing gelatin softgel manufacturing processes, LYCAGEL® Premix promises all the benefits of our unique market-first pea starch technology which…
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Spironolactone (SPL), a potent anti-aldosterone steroidal drug used to treat several diseases in paediatric patients (e.g., hypertension, primary aldosteronism, Bartter’s syndrome, and congestive heart failure), is not available in child-friendly dosage forms, and spironolactone liquids have been…
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Caking in amorphous powders compromises their quality during storage. Individual particles absorb water vapor, which changes their viscosity and promotes the formation of sinter bridges. Lumps of particles grow and eventually span the whole powder, affecting the mechanical properties and quality of…
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The present study documents the drug-excipient incompatibility in the physical mixtures and its influence on bulk homogeneity and flowability for dry powder inhalers (DPI) applications. Binary mixtures with the model drugs (aceclofenac; salbutamol sulphate) and lactose monohydrate were prepared…
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Roquette’s NEW premix solution for veggie softgel formulation is here – a ready-to-use, plant-based blend for nutraceutical AND pharmaceutical softgel formulations. LYCAGEL® Premix is easily incorporated into existing manufacturing processes and can help you bring your products to market faster –…
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Bosentan is choice of drug for pulmonary arterial hypertension. It belongs to BCS class-II category. Due to poor solubility in aqueous media, treatment leads to frequent dosing & increasing cost of therapy subsequently. One cannot unseen the shortcomings of commonly existing solubility…
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Flufenamic acid (FFA) is a non-steroidal anti-inflammatory drug characterised by a low solubility and problems of variable dissolution rate and bio-inequivalence. Different FFA batches, obtained by different suppliers, showed different powder characteristics (particle size, shape and surface…
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The continuous manufacturing of solid oral-dosage forms represents an emerging technology among the pharmaceutical industry, where several process steps are combined in one production line. As all mixture components, including the lubricant (magnesium stearate), are passing simultaneously through…
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