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Roquette
Influence of the Infill Geometry of 3D-Printed Tablets on Drug Dissolution
Abstract
Patient-centric therapy is especially important in pediatrics and may be attained by three-dimensional printing. Filaments containing 30% w/w of theophylline were produced by hot-melt extrusion and printed using fused deposition modelling to produce tablets. Here, preliminary results…
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Pharmacotechnical and Analytical Preformulation Studies for Cannabidiol Orodispersible Tablets
Obtaining orodispersible tablets (ODT) containing substances from the 2nd Biopharmaceutical Class has raised concerns as the dissolution test is challenging. This study aimed to select suitable excipients for developing orodispersible tablets containing cannabidiol (CBD) by direct compression…
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Orodispersible Film Loaded with Enterococcus faecium CRL183 Presents Anti-Candida albicans Biofilm…
Background: Probiotic bacteria have been emerging as a trustworthy choice for the prevention and treatment of Candida spp. infections. This study aimed to develop and characterize an orodispersible film (ODF) for delivering the potentially probiotic Enterococcus faecium CRL 183 into the oral cavity,…
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Microfibrous cyclodextrin boosts flame retardancy of poly(lactic acid)
2-hydroxypropyl-β-cyclodextrin (HP-β-CD) microfibres with diameters ranging between 3-7 µm were prepared by aqueous solution based high-speed electrospinning (HSES) technique and then used as carbonising agent at 3 wt% loading besides 15 wt% ammonium polyphosphate (APP) to obtain…
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Spray-Congealing and Wet-Sieving as Alternative Processes for Engineering of Inhalation Carrier…
Purpose
Traditionally, α-lactose monohydrate is the carrier of choice in dry powder inhaler (DPI) formulations. Nonetheless, other sugars, such as D-mannitol, have emerged as potential alternatives. Herein, we explored different particle engineering processes to produce D-mannitol carriers for…
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Continuous downstream processing of milled electrospun fibers to tablets monitored by near-infrared…
Electrospinning is a technology for manufacture of nano- and micro-sized fibers, which can enhance the dissolution properties of poorly water-soluble drugs. Tableting of electrospun fibers have been demonstrated in several studies, however, continuous manufacturing of tablets have not been realized…
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Emulsification Speed of Amphiphilic Starches
Amphiphilic starches (sodium octenylsuccinate starches) are a well‐known emulsifier for various food and pharma applications. Typical applications are the encapsulation of lipophilic compounds such as vitamins and other micronutrients or the direct or indirect solubilization of drug substances . To…
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Chlorhexidine Mucoadhesive Buccal Tablets: The Impact of Formulation Design on Drug Delivery and…
Oropharyngeal candidiasis (OPC) is a mucosal infection caused by Candida spp., and it is common among the immunocompromised. This condition is mainly treated using oral antifungals. Chlorhexidine (CHD) is a fungicidal and is available as a mouth wash and oral gel. It is used as an adjuvant in the…
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The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of…
The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation. This system was also proposed in a colon-targeting…
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Poster: Granfiller-D® & Hisorad® As New Co-processed Excipients For Orally Disintegrating…
Introduction: Tablets are still the most widely used dosage form for oral application due to their simple administration and relatively low manufacturing costs. One main disadvantage of tablets is the difficulty in swallowing or chewing. This is especially relevant for special patient groups, e.g.…
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