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Roquette
Taste Masking Study Based on an Electronic Tongue: the Formulation Design of 3D Printed…
Purpose
Proper taste-masking formulation design is a critical issue for instant-dissolving tablets (IDTs). The purpose of this study is to use the electronic tongue to design the additives of the 3D printed IDTs to improve palatability.
Methods
A binder jet 3D printer was used to prepare…
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Combination of PAT and mechanistic modeling tools in a fully continuous powder to granule line:…
Comprehensive understanding of an integrated continuous pharmaceutical technology was achieved in this study by a combining design of experiments and mechanistic modeling-based simulations. The powder to granule line consisted of twin-screw wet granulation, vibrational fluid-bed drying and milling.…
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The Development of Minitablets for a Pediatric Dosage Form for a Combination Therapy
Minitablets are an appealing option for an age-appropriate pediatric dosage form. In particular, for combination therapies where multiple active ingredients are dosed simultaneously, the use of minitablets will enable independent adjustments of each dose. The work presented describes the development…
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Development and Characterization of Excipient Enhanced Growth (EEG) Surfactant Powder Formulations…
This study aimed to develop and characterize a spray-dried powder aerosol formulation of a commercially available surfactant formulation, Survanta® intratracheal suspension, using the excipient enhanced growth (EEG) approach. Survanta EEG powders were prepared by spray drying of the feed dispersions…
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Amorphous Solid Dispersion Tablets Overcome Acalabrutinib pH Effect in Dogs
Calquence® (crystalline acalabrutinib), a commercially marketed tyrosine kinase inhibitor (TKI), exhibits significantly reduced oral exposure when taken with acid-reducing agents (ARAs) due to the low solubility of the weakly basic drug at elevated gastric pH. These drug–drug interactions (DDIs)…
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Formulation and process strategies to minimize coat damage for compaction of coated pellets in a…
Compaction of multiple-unit pellet system (MUPS) tablets has been extensively studied in the past few decades but with marginal success. This study aims to investigate the formulation and process strategies for minimizing pellet coat damage caused by compaction and elucidate the mechanism of damage…
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Formulate and Evaluate Famciclovir Floating Tablets
Floating drug delivery system of famciclovir was developed to prolong gastric residence time, target stomach mucosa and increase drug bioavailability by using different polymers like HPMC E15, Xanthan gum, methyl cellulose and compritol 888 ATO with different concentration. Famciclovir capable of…
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Impact of co-processed excipient particles solidity and circularity on critical quality attributes…
The selection of appropriate functional co-processed excipient (CPE) is a crucial stage in orodispersible minitablets (ODMTs) development. This paper aimed to identify the most important morphological attributes influencing the flowability and homogeneity of powder mixtures and minitablets final…
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Rapid prototyping of miniaturized powder mixing geometries
Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing.…
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Roquette’s Video Blog: Ask the Experts
See the newest publication from Roquette's video blog here
Ask the experts: "One way that biopharmaceutical manufacturers can keep up with demands in the industry, is by streamlining complex workflows. But to do this, they need innovative technologies."
Click to watch the video:
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