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Roquette
Influence of high pressure compaction on solubility and intrinsic dissolution of ibuprofen binary…
Enabling formulations often depend on functional excipients. However, the question remains whether excipients regarded as standard establish similar interactions and subsequently improvement of solubility when employed at unusual manufacturing process conditions.
In this study, compaction of API…
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Functionality evaluation of co-processed excipients
Tablets constitute about 80–90% of dosage forms commonly prescribed by medical practitioners for therapeutic management of disease conditions. It is a solid dosage form that exercises advantages over other dosage forms because of its ease of administration, stability profile and amenable to…
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Quality by Design Applied Development of Immediate-Release Rabeprazole Sodium Dry-Coated Tablet
The aim of this study was to develop immediate-release oral rabeprazole sodium tablets with rapid efficacy and gastric stability for the treatment of gastroesophageal reflux disease. Rabeprazole sodium is a commonly prescribed proton pump inhibitor; however, it is extremely unstable and degrades in…
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In situ forming and mucoadhesive ophthalmic voriconazole/HPβCD hydrogels for the treatment of fungal…
Fungal keratitis is a severe infectious corneal disease. At present, no voriconazole ophthalmic formulations are approved by the FDA or EMA. This lack of therapeutic options leads to the reformulation of intravenous voriconazole preparations (VFEND®) by the hospital pharmacy departments to prepare…
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Co-Processed Excipients for Dispersible Tablets—Part 2: Patient Acceptability
Palatability and patient acceptability are critical attributes of dispersible tablet formulation. Co-processed excipients could provide improved organoleptic profile due to rational choice of excipients and manufacturing techniques. The aim of this study was to identify the most suitable…
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Challenges of Dissolution Methods Development for Soft Gelatin Capsules
Recently, the development of soft gelatin capsules (SGCs) dosage forms has attracted a great deal of interest in the oral delivery of poorly water-soluble drugs. This is attributed to the increased number of poorly soluble drugs in the pipeline, and hence the challenges of finding innovative ways of…
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Niclosamide Inhalation Powder Made by Thin-Film Freezing: Pharmacokinetic and Toxicology Studies in…
In this work, we have developed and tested in vivo a dry powder form of niclosamide made by thin-film freezing (TFF) and administered it by inhalation to rats and hamsters. The niclosamide dry powder, suitable for inhalation, is being developed as a therapeutic agent against COVID-19 infection.…
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Comparison of Compressibility, Compactability, and Lubricant Sensitivity of Two Partially…
Modified starches are widely employed excipients in tablets compression. The ability of materials to deform under pressure (compressibility) and create strong compacts (compactability) is then important for tablet manufacture. This study aims to evaluate and compare two partially pregelatinized…
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Formulation and stability study of hydroxychloroquine sulfate oral suspensions
Hydroxychloroquine is an antimalarial drug indicated in the treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also used for the treatment of rheumatoid arthritis, discoid and systemic lupus erythematosus, and more…
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Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in…
Dapagliflozin (DAP), which improves glycemic control in patients with type 2 diabetes mellitus, has poor physical properties against heat and moisture, thus hindering its manufacturing potential. The superior physicochemical properties of a recently developed cocrystal of DAP and citric acid (DAP…
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