Browsing Category
Roquette
Investigation of hydroxypropyl-β-cyclodextrin inclusion complexation of two poorly soluble model…
The goal for any formulation design of poorly soluble drugs is to increase the solubility. However, increased solubility is a challenge when the drug is administered to the oral cavity as rapidly dispersing or mucoadhesive buccal films. Most drugs are bitter and increased solubility may correlate…
Read More...
Read More...
Integrated Twin-Screw Wet Granulation, Continuous Vibrational Fluid Drying and Milling: A fully…
Highly homogeneous low-dose (50 µg) tablets were produced incorporating perfectly free-flowing granules prepared by a fully integrated Continuous Manufacturing (CM) line. The adopted CM equipment consisted of a Twin-Screw Wet Granulator (TSWG), a Continuous Fluid Bed Dryer (CFBD) and a Continuous…
Read More...
Read More...
A novel approach to determine the granule density of milled ribbons using multi-stage air…
Determination of the granule density as a critical quality attribute during roller compaction/dry granulation provides an important parameter for further successful processing of the compacted materials. In this study, a novel approach was developed to determine the granule density using the…
Read More...
Read More...
Pharmaceutical applications of aqueous scaled-up electrospinning
Thesis findings
A solid formulation of a model biopharmaceutical drug (β-galactosidase) was developed and produced by high-speed electrospinning for the first time. A fully aqueous polymeric solution was successfully electrospun with a 30 mL/h feeding rate, which is about 30x higher than the…
Read More...
Read More...
Melt Milling as Manufacturing Method for Solid Crystalline Suspensions
Production of submicron particles (0.1-1 µm) has been identified by the pharmaceutical industry as a key technology to enhance the bioavailability of poorly water-soluble drugs. However, nanosuspensions derived from commonly applied wet milling suffer from long-term stability issues, making further…
Read More...
Read More...
Unlocking production efficiency with Roquette’s Precision Dispense service
A fully customized single-use packaging solution
Now available for Roquette’s full biopharma portfolio including:
KLEPTOSE® HP/HPB BioPharma 2-hydroxypropyl-betacyclodextrin
NEOSORB® BioPharma sorbitol
PEARLITOL® BioPharma mannitol
LYCADEX® BioPharma dextrose monohydrate
Dextrose…
Read More...
Read More...
Comparison of Compressibility, Compactability and Lubricant Sensitivity of Two Partially…
Modified starches are widely employed excipients in tablets compression. The ability of materials to deform under pressure (compressibility) and create strong compacts (compactability) is then important for tablet manufacture. This study aims to evaluate and compare two partially pregelatinized…
Read More...
Read More...
LYCAGEL™ – Roquette’s Innovative Plant-Based Solution Unlocks Possibilities for Veggie Softgel…
Market-first plant-based softgel system provides a strong alternative to gelatin for nutraceutical and pharmaceutical manufacturers and marketers of softgel products
GENEVA, Illinois. (November 18, 2020) - Roquette, a global leader in plant-based ingredients, pioneer of plant proteins and…
Read More...
Read More...
Insights into the Moisture Scavenging Properties of Different Types of Starch in Tablets Containing…
Starch is a commonly used excipient in the pharmaceutical industry. However, information on the effect of the moisture scavenging properties of starch to protect moisture-sensitive drugs is limited. The interaction between starch and moisture is of particular interest as moisture fugacity can impact…
Read More...
Read More...
A multivariate statistical approach to analyze the impact of material attributes and process…
The purpose of this work is to develop a statistical methodology that identifies the correlations among critical material attributes, critical process parameters, and critical quality attributes of a volumetric vertical micro-auger dosing process. This contributes to improving the accuracy and…
Read More...
Read More...