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Roquette
Piroxicam ternary solid dispersion system for improvement of dissolution (%) and in vitro…
The improvement of drug solubility is a challenging task in the pharmaceutical industry; moreover, drug stability is also important. This study was designed to improve the dissolution (%) and in vitro anti-inflammation effects of piroxicam (PRX) and maintain its stability using a ternary solid…
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Electrospun Solid Formulation of Anaerobic Gut Microbiome Bacteria
A model anaerobic bacterium strain from the gut microbiome (Clostridium butyricum) producing anti-inflammatory molecules was incorporated into polymer-free fibers of a water-soluble cyclodextrin matrix (HP-β-CD) using a promising scaled-up nanotechnology, high-speed electrospinning. A long-term…
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Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin…
A new cyclodextrin polypseudorotaxanes nail lacquer (Regenail®) containing biotin, methyl sulphonyl methane (MSM), and dimethylsilanediol salicylate was developed and evaluated in vitro and in vivo. The product was developed to improve nail status and diminish signs of pathological nail alterations.…
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New Research Reveals a Promising Functional Alternative to Surfactants within Biologic Formulations
One of the most common challenges when formulating biological molecules for therapeutic use is overcoming the molecules’ tendency to aggregate. Currently, the nonionic surfactants polysorbate 80 and polysorbate 20 are widely used to stabilize proteins in liquid preparations for parenteral…
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Characterization and modeling of the viscoelasticity of pharmaceutical tablets
Evolution of the compaction properties of powders with the compaction speed (strain rate sensitivity, SRS) is a common phenomenon during the manufacturing of pharmaceutical tablets. Nevertheless, several different phenomena can be responsible of the SRS like friction, viscoelasticity,…
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Orodispersible Tablets (ODTs) – Overcoming you main challenges
Orally Disintegrating Tablets (ODTs) are getting increasingly interesting delivery systems in the pharmaceutical and nutraceutical fields. They are an innovative way to handle the product lifecycle management, generate market differentiation, and increase the interest of consumers.
This webinar…
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Development of a stable oral pediatric solution of hydrochlorothiazide by the combined use of…
Hydrochlorothiazide (HCT) is widely used in pediatrics for hypertension management. Due to the lack of pediatric commercial forms, community or hospital pharmacies generally prepare HCT extemporaneous pediatric suspensions by dispersing in water a portion of a crushed tablet or the drug powder;…
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Evaluation of an external lubrication system implemented in a compaction simulator
The internal blending of magnesium stearate is often associated with decreasing tensile strengths and longer disintegration and dissolution times. Therefore, external lubrication has gained interest in the pharmaceutical industry as these negative effects could be minimized using this method. In…
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Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of…
Hydrophilic matrix tablets are a type of sustained release dosage form characterized by distributing a drug in a matrix that is usually polymeric. Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase. In recent years, it has been shown that tolcapone is a potent inhibitor of…
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Biopharmaceutical implications of excipient variability on drug dissolution from immediate release…
Elucidating the impact of excipient variability on oral product performance in a biopharmaceutical perspective would be beneficial and allow excipient implementation on Quality by Design (QbD) approaches. The current study investigated the impact of varying viscosity of binders (hypromellose (HPMC))…
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