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Roquette
Development of Low Dose Micro-tablets by High Shear Wet Granulation Process
Low dose micro-tablets with acceptable quality attributes, specifically content uniformity (CU), would not only enhance the dose flexibility in the clinic, but also decrease excipient burden in pediatric population. Considering the CU challenges associated with directly compressed low dose…
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In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations
The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it dicult to achieve therapeutic levels…
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Tackling Coronavirus: The role of Roquette’s KLEPTOSE® HPβCD in the fight against COVID-19 –…
Hydroxypropyl β-cyclodextrin (HPβCD) has been shown to be effective as solubilizing and stabilizing agents in vaccines, monoclonal antibodies, and oral formulations.
Watch our expert video, featuring Pharma and BioPharma Scientists – Dr. Foo Wen Chin and Dr. Peng Tao – who explain how Roquette’s…
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StarLac® for Orally Disintegrating Tablets
Oral application of drugs is not only the most common way for systemic drug application, it is also patient’s route of choice. Oral formulations are – compared to injections or infusions – convenient and painless. As they do not require sterility they are cost effective and reveal good patient…
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continuous twin screw granulation and fluid bed drying: a mechanistic scaling approach focusing…
This study provides the results of investigation on scaling approaches for three differently-sized continuous granulation lines, each consisting of a twin screw wet granulation process and a continuous fluid bed drying process. To check the initial scaling approach with regard to granule and tablet…
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Erodible Coatings Based on HPMC and Cellulase for Oral Time-Controlled Release of Drugs
Oral drug delivery systems for time-controlled release, intended for chronotherapy or colon targeting, are often in the form of coated dosage forms provided with swellable/soluble hydrophilic polymer coatings. The latter are responsible for programmable lag phases prior to release, due to their…
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Quantification of tablet sensitivity to a stress concentration: Generalization of Hiestand’s…
Sensitivity to a stress concentration is important for the development of pharmaceutical tablets as it is related to defects like capping. The Brittle Fracture Index (BFI) was introduced by Hiestand et al. to test this sensitivity. Recently, a more general index, based on the average stress…
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Combating Coronavirus: Key Role of Cyclodextrins in Treatment and Prevention
A new strain of coronavirus (2019-nCoV) started to emerge in late December 2019 from Wuhan, the capital of Hubei Province in central China, which is a city with a population of 11 million. The pneumonia- like illness, which has spread rapidly since first appearing in late December 2019, was declared…
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Roquette launches an online technical platform for researchers and drug developers
The new platform – “Innovation Hub” – and its virtual assistant – “Rosa”- offer pharmaceutical scientific community new opportunities for formulation ideas and information exchange
Geneva, IL (USA), March 31, 2020 – As virtual collaboration and knowledge-sharing have reached a new level of…
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Model-dependent pharmacokinetic analysis of enalapril following the administration of novel…
Despite the legislative initiatives by the regulatory European medical agency (EMA) and the United States Food and Drug Administration Authority (FDA), an approved drug with child-appropriate dosage formulations are still absent for many drugs for pediatric heart failure. The pediatric patients are…
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