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Roquette
Biocompatible hydroxy double salt tablet formulations
Generally, commercial extended release tablets are core-based, which can cause problems for certain patients if they split them prior to ingestion. There is a need to develop non-core-based extended release tablets. We have previously reported the synthesis of two new biocompatible hydroxy double…
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Structural modifications for the conversion of proteins and peptides into stable dried powder…
The drying of biomolecules into powdered formulations has become the main form of long-term product stabilisation, allowing for the delivery of safe and efficient medicines. Stability of proteins and peptides during the drying process is paramount for product quality. Drying macromolecules with an…
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CPHI Barcelona 2023 – with a focus on excipients
This year CPHI Europe opens its doors in Barcelona at Fira Barcelona Gran Via.
From 24th to 26th October you can have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack,
P-MEC, FDF, ICSE and BioProduction will be held together with CPHI.
Pharma Excipients gives you an…
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Influence of beta-cyclodextrin on the phase transition in carbamazepine polymorphs
Introduction
Carbamazepin (CBZ), a widespread used antiepileptic drug, branded as Tegretol, firstly was launched in form of Active Pharmaceutical Ingredient (API) as a commercially available polymorphic form III. Additionally, crystallographic studies on crystal packing motifs of carbamazepine…
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Investigating the Impact of Co-processed Excipients on the Formulation of Bromhexine Hydrochloride…
Abstract
Purpose
Orodispersible tablets (orally disintegrating tablets, ODTs) have been used in pharmacotherapy for over 20 years since they overcome the problems with swallowing solid dosage forms. The successful formula manufactured by direct compression shall ensure acceptable mechanical…
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Leveraging a multivariate approach towards enhanced development of direct compression extended…
Extended release formulations play a crucial role in the pharmaceutical industry by maintaining steady plasma levels, reducing side effects, and improving therapeutic efficiency and compliance. One commonly used method to develop extended release formulations is direct compression, which offers…
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Comparison of properties on Orally Disintegrating Tablets (ODTs) produced by direct compression or…
Abstract
Orally disintegrating tablets (ODTs) is a popular drug delivery system as they dissolve in the mouth, usually within seconds which enables easy medication for patients with problem swallowing. In this thesis properties of ODTs were compared when produced with direct compression of the…
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Effects of wet granulation process variables on the quantitative assay model of transmission Raman…
Transmission Raman spectroscopy (TRS) is a process analytical technology tool for nondestructive analysis of drug content in tablets. Although wet granulation is the most used tablet manufacturing method, most TRS studies have focused on tablets manufactured via direct compression. The effects of…
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Formulation of Silymarin-β Cyclodextrin-TPGS Inclusion Complex: Physicochemical Characterization,…
Abstract
Silymarin (SIL) is a poorly water-soluble flavonoid reported for different pharmacological properties. Its therapeutic applications are limited due to poor water solubility. In this study, the solubility of silymarin has been enhanced by preparing freeze-dried binary and ternary complexes…
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Carboxymethyl starch films as enteric coatings: Processing and mechanistic insights
This study proposes the application of carboxymethyl starch derivatives as tablet coatings affording gastro-protection. Carboxymethyl starch (CMS) films were obtained by casting of aqueous filmogenic starch solutions with or without plasticizers and their structural organization was followed using…
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