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Seppic
A quality by design framework for developing nanocrystal bioenabling formulations
The present study aims to outline a rational framework for the design and development of a 1.0% (w/v) hydrocortisone nanocrystal-based formulation, resorting to a simple, efficient, and scalable nanonization methodology, based on the high-pressure homogenization (HPH) technique. Accordingly, the…
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Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines
Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines and develop new vaccination strategies and vaccine platforms…
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Accelerating Topical Drug Development Through Initial Excipient Selection
See the poster presented by Seppic at DDF Summit in Berlin in June 2023:
Introduction
Novel topical drug development will require multiple formulation adjustments from the initial formulation studies to the registration phase .
Common issues encountered are API chemical instability, API lack…
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In vitro-in vivo relationship for amorphous solid dispersions using a double membrane…
The use of amorphous solid dispersions (ASDs) is one commonly applied formulation strategy to improve the oral bioavailability of poorly water-soluble drugs by overcoming dissolution rate and/or solubility limitations. While bioavailability enhancement of ASDs is well documented, it has often been a…
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Dual-Drug-Loaded Topical Delivery of Photodynamically Active Lipid-Based Formulation for Combination…
Topical administration of anti-cancer drugs along with photodynamically active molecules is a non-invasive approach, which stands to be a promising modality for treating aggressive cutaneous melanomas with the added advantage of high patient compliance. However, the efficiency of delivering drugs…
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SEPISMART™ SR – Time to release your creativity
See the new Seppic product SEPISMART™ SR in use cases with Vitamin C and caffein delivery:
INTESTINAL ABSORPTION - a critical step
1. At physiological pH, vitamin C is mainly found in its ionized form, named ascorbate (Asc) and to a lesser extent in its oxidized form, called…
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Efficient Development of Green Emulsifier/Emollient-Based Emulsion Vehicles: From RSM Optimal…
Since natural-origin, sustainable ingredients are preferred by modern consumers, novel emulsifiers and emollients keep entering the market. This study hypothesizes that a combination of in silico, instrumental tools and simplified sensory studies could be used to efficiently characterize emulsions…
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Sepifilm NATurally COLored
Film-coating agent formulated without TiO2, aluminium and artificial colors
Current solutions in tablet coating make it hard to both meet the growing demand for naturalness from consumers and to comply with stricter regulations, especially in Europe.
SEPIFILM™ NATurally COLored by Seppic are…
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Your visit at CPHI worldwide 2022 in Frankfurt
CPHI worldwide opens its doors again. This year in Frankfurt at the Messe Frankfurt. In two weeks, from 1st to 3rd November, you can finally have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack, P-MEC, FDF, ICSE and BioProduction will be held together with CPHI.
The…
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Fabrication and Characterizations of Pharmaceutical Emulgel Co-Loaded with Naproxen-Eugenol for…
The aim of this study was to fabricate and characterize a pharmaceutical emulgel co-loaded with naproxen/eugenol for transdermal delivery to improve the analgesic and anti-inflammatory effects and to eliminate GIT adverse reactions. Emulgel was prepared using a slow emulsification method and…
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