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Seppic
Formulation Strategies to Improve the Stability and Handling of Oral Solid Dosage Forms of Highly…
Highly hygroscopic pharmaceutical and nutraceutical solids are prone to significant changes in their physicochemical properties due to chemical degradation and/or solid-state transition, resulting in adverse effects on their therapeutic performances and shelf life. Moisture absorption also leads to…
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Semisolid Wet Sol–Gel Silica/Hydroxypropyl Methyl Cellulose Formulation for Slow Release of Serpin…
Foot ulcerations are a disabling complication of diabetes and no treatment is currently available based on disease mechanisms. The protein serpin B3 (SB3) was identified as a positive biomarker of successful diabetic wound healing; therefore, its exogenous administration may promote healing. The…
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Squalene in oil-based adjuvant improves the immunogenicity of SARS-CoV-2 RBD and confirms safety in…
COVID-19 pandemic has accelerated the development of vaccines against its etiologic agent, SARS-CoV-2. However, the emergence of new variants of the virus lead to the generation of new alternatives to improve the current sub-unit vaccines in development. In the present report, the immunogenicity of…
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Filament-based 3D-printing of placebo dosage forms using brittle lipid-based excipients
In order to expand the limited portfolio of available polymer-based excipients for fabricating three-dimensional (3D) printed pharmaceutical products, Lipid-based excipients (LBEs) have yet to be thoroughly investigated. The technical obstacle of LBEs application is, however their crystalline nature…
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Downstream Processing of Itraconazole:HPMCAS Amorphous Solid Dispersion: From Hot-Melt Extrudate to…
The downstream processing of hot-melt extruded amorphous solid dispersions (ASDs) into tablets is challenging due to the low tabletability of milled ASDs. Typically, the extrudate strand is sized before milling, as the strand cannot be fed directly into the milling system. At the lab scale, the…
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Material optimization for the development of delayed release formulation using computational tools
The present study involves designing a delayed-release tablet formulation of a drug belonging to BCS class-III further chemically classified as bisphosphonate to improve bioavailability. The typical approach to drug design experimentation calls for only one variable to be altered at a time, with all…
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Formulation Development and Optimization of Bioenhanced Sublingual Tablets of Rizatriptan Benzoate…
The drugs belonging to BCS class III, create various challenges for the development of sublingual dosage form due to poor absorption through sublingual mucosa. The sublingual drug delivery is suitable for potent drugs only and prevents the firstpass metabolism of drugs, leading to its direct…
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API-polymer interactions in Sepineo P600 based topical gel formulation – impact on rheology
In the present study, topical gel and emulsion gel were formulated using Acrylamide/ Sodium Acryloyldimethyl taurate copolymer (Sepineo P600) as a gelling agent, and their rheological attributes and physical stability were evaluated upon incorporation of API. Lidocaine, a free base drug (pKa 7.92)…
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Ensuring Product Stability – Choosing the Right Excipients
The stability of pharmaceuticals is an important product quality attribute. Of the known factors affecting stability, moisture is often perceived as the most common cause of drug degradation by hydrolysis or other reactions facilitated by moisture as a medium. Excipients are a critical entity in…
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Osmolality of Excipients for Parenteral Formulation Measured by Freezing Point Depression and Vapor…
Purpose
To investigate the difference in methods to determine the osmolality in solutions of stabilizers used for long-acting injectable suspensions.
Methods
The osmolality was measured by freezing point depression and vapor pressure for 11 different polymers and surfactants (PEG 3350, 4000,…
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