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Shin-Etsu
Synergistic effect of polymers in stabilizing amorphous pretomanid through high drug loaded…
Pretomanid (PTM), an oral antibiotic used in the treatment of adults with pulmonary extensively drug-resistant, nonresponsive multidrug-resistant tuberculosis (MDR-TB). It is a poor glass former, that shows high recrystallization tendency from the amorphous and supersaturated state, resulting in low…
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Lessons to learn for 3D printing of drug products by semisolid extrusion (SSE)
Abstract
Semisolid extrusion (SSE) 3DP technology is emerging due to its simplicity and potential for on-site manufacturing of personalized drug products with tailored functionality (dose, release profile), as well as recognizability (size, shape, color). However, even a minor change in the…
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Advantages of combining polymers and lipids in extrusion processes
This poster was presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
Hot melt extrusion (HME) has become increasingly popular in pharmaceutical manufacturing over the last
decade1. This…
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TYLOPUR® – Water soluble cellulose ethers by Shin-Etsu
Introduction
TYLOPUR® is Hypromellose (HPMC) and a versatile pharmaceutical excipient. TYLOPUR® is manufactured at Tyloshin 2 plant at SE Tylose GmbH & Co. KG in Wiesbaden, Germany. This plant operates under GMP conditions and fulfills the requirements of the pharmaceutical industry. SE Tylose…
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HPMCP – Cellulose derivative for enteric coating by Shin-Etsu
Since the introduction of HPMCP (hypromellose phthalate USP/NF, JP, EP) in 1971, it has proved its value in enteric coating using organic solvent. The chemical structure of HPMCP is a monophthalic acid ester of hypromellose.The threshold pH value for rapid disintegration of HPMCP can be controlled…
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L-HPC – Multifunctional excipient for oral solid dose by Shin-Etsu
L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) was developed by Shin-Etsu and first approved in 1977 as a disintegrant for tablets in Japan. New grades were developed during the last years in order to cover the needs for our customer having best solutions for individual applications.…
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A comprehensive assessment of machine learning algorithms for enhanced characterization and…
Orodispersible films (ODFs) have emerged as innovative pharmaceutical dosage forms, offering patient-specific treatment through adjustable dosing and the combination of diverse active ingredients. This expanding field generates vast datasets, requiring advanced analytical techniques for deeper…
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METOLOSE® – Binder and Thickening Agent
Hydroxy propyl methyl cellulose (Hypromellose) and methyl cellulose are produced by Shin-Etsu Chemical Co., Ltd. since 1960s under the trade name METOLOSE®. For methyl cellulose, several grades are available, and they differ in viscosity.For hydroxy propyl methyl cellulose they differ in viscosity…
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Enzyme-Linked Lipid Nanocarriers for Coping Pseudomonal Pulmonary Infection
Would Nanocarriers Complement Biofilm Disruption or Pave Its Road?
Introduction: Cystic fibrosis (CF) is associated with pulmonary Pseudomonas aeruginosa infections persistent to antibiotics.
Methods: To eradicate pseudomonal biofilms, solid lipid nanoparticles (SLNs) loaded with…
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PHARMACOAT® – Easy to use film coating material that provides an excellent finish
Shin-Etsu Chemical supplies the various excipients for pharmaceutical industry and developed PHARMACOAT® in the 1960s during the early days of film coating and since then it has been the subject of a continuous development and quality improvement.
The PHARMACOAT® grades are low viscous…
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