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Shin-Etsu
Polymeric Films Containing Tenoxicam as Prospective Transdermal Drug Delivery Systems: Design and…
The administration of drugs via transdermal therapeutic systems has become an attractive form of therapeutic approach, considering its advantages and the high patient compliance achieved, making them a viable alternative, especially in the treatment of chronic diseases.
The purpose of our study…
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Development of a Pediatric Mini-Tablet Formulation for Expedited Preclinical Studies
Multiple considerations are essential to address the main challenges of dose flexibility and patient adherence in pediatric drug development, particularly for oncology. Mini-tablets, 2 mm in diameter, were manufactured using a rotary tablet press at a set weight and compression force level. The…
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3D printed bilayer tablet with dual controlled drug release for tuberculosis treatment
In this study Fusion Deposition Modelling (FDM) was employed to design and fabricate a bilayer tablet consisting of isoniazid (INZ) and rifampicin (RFC) for the treatment of tuberculosis. INZ was formulated in hydroxypropyl cellulose (HPC) matrix to allow drug release in the stomach (acidic…
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Design of a pH-responsive oral gel formulation based on the matrix systems of gelatin/hydroxypropyl…
Extensive efforts have been directed toward developing novel easily digested formulations with desirable controlled-release properties. The present study sought to develop pH-responsive oral gel formulations using combinations of gelatin and enteric polymers for controlled drug release under…
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Effect of Disintegrants on Prolongation of Tablet Disintegration Induced by Immersion in Xanthan…
In clinical practice, a thickening solution is frequently used to allow easy swallowing of tablets by patients suffering from dysphagia. This study investigated the effect of the thickening solution on tablet disintegration. Model tablets containing different disintegrants were prepared and their…
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Overcoming the Solubility Barrier of Ibuprofen by the Rational Process Design of a Nanocrystal…
Wet media milling, coupled with spay drying, is a commonly proposed formulation strategy for the production and solidification of nanosuspensions in order to overcome the solubility barrier of BCS Class II substances. However, the application of mechanically and thermally intensive processes is not…
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Development of probiotic orodispersible tablets using mucoadhesive polymers for buccal mucoadhesion
Objective: Probiotic bacteria, such as different lactobacilli strains, have successfully been used to treat gingivitis and periodontitis or caries. By formulating probiotics as orodispersible tablet (ODT), the benefits of this dosage form could be utilised. Without any further measures, the…
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Comparison of Different Liquid and Semisolid Vehicles Selected for Oral Administration of Pellets…
The acceptability and palatability of a dosage form are extremely important to improve patient compliance. Mixing oral solid dosage forms with food carriers is often necessary to ease swallowing and provide the taste-masking effect. The present research investigated how a liquid or semisolid carrier…
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In Vitro Evaluation of Enteric-Coated HPMC Capsules – Effect of Formulation Factors on Product…
A comparative study on different enteric-coated hard capsules was performed. The influence of different formulation factors like choice of enteric polymer, triethyl citrate (TEC) concentration (plasticizer), talc concentrations (anti-tacking agent), and different coating process parameters on the…
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Sustained release – made from nature with Tylopur Xtend Nutra®
XTENDED RELEASE OF ACTIVE INGREDIENTS FOR NUTRACEUTICAL & NUTRITIONAL APPLICATIONS
Tylopur Xtend Nutra® is a plant derived cellulose-based ingredient produced by Shin-Etsu. It is specifically developed for nutraceutical and nutritional applications. It enables xtended release of…
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