Browsing Category
Shin-Etsu
Characterization of ternary amorphous solid dispersion containing hypromellose phthalate and…
Hot melt extrusion is a promising technology for producing amorphous solid dispersions, however, there is a risk of thermal degradation or residual crystallinity formation. This caveat may be addressed by optimizing formulations and manufacturing conditions. The aim of our study was to explore…
Read More...
Read More...
Characterization and comparison of deferasirox fast disintegrating tablets prepared by direct…
The aim of this study was to develop direct compressed and lyophilized fast disintegrating/dissolving tablets (FDTs) that enhanced disintegration and dissolution of deferasirox, a drug with poor solubility and bioavailability. Although there are conventional oral tablets and tablets for oral…
Read More...
Read More...
The manufacture of fixed dose combination products using advanced pharmaceutical techniques for the…
Thesis by Jeremiah Kelleher, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, The University of Dublin
The thesis has focused on the use of continuous manufacturing techniques to produce fixed dose combination (FDC) products for the treatment of type II diabetes mellitus…
Read More...
Read More...
Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid…
Drug delivery of poorly soluble drugs in form amorphous solid dispersions (ASDs) is an appealing method to increase in vivo bioavailability. For rational formulation design, a mechanistic understanding of the impact of surfactants on the performance of ASD-based formulations is therefore of…
Read More...
Read More...
Blend of cellulose ester and enteric polymers for delayed and enteric coating of core tablets of…
The focus of this work was to explore feasibility of using blends of cellulose esters (CA 320S, CA 3980-10 or CAB 171-15) and enteric polymers (C-A-P, Eudragit® L100 or HPMCP HP-55) for delayed and enteric coating of tablets containing either diclofenac sodium (DFS, high dose) or prednisone (PDS,…
Read More...
Read More...
Co-Processed Excipients for Dispersible Tablets—Part 2: Patient Acceptability
02. July 2018
Palatability and patient acceptability are critical attributes of dispersible tablet formulation. Co-processed excipients could provide improved organoleptic profile due to rational choice of excipients and manufacturing techniques. The aim of this study…
Read More...
Read More...
Co-Processed Excipients for Dispersible Tablets Part 1: Manufacturability
24. June 2018
Co-processed excipients may enhance functionality and reduce drawbacks of traditional excipients for the manufacture of tablets on a commercial scale. The following study aimed to characterise a range of co-processed excipients that may prove suitable for…
Read More...
Read More...
A novel approach to support formulation design on twin screw wet granulation technology:…
The overall objective of this work is to understand how excipient characteristics influence the drug product quality attributes and process performance of a continuous twin screw wet granulation process. The knowledge gained in this study is intended to be used for Quality by Design (QbD)-based…
Read More...
Read More...
Tailoring supersaturation from amorphous solid dispersions
15. April 2018
The maximum achievable concentration of a drug in solution is dictated by the chemical potential of the solid form. Because an amorphous solid has a higher chemical potential than the correspondingcrystal form, in the absence of phase transformations, a…
Read More...
Read More...
Optimized tableting for extremely oxygen-sensitive probiotics using direct compression
10. January 2018
Abstract
Faecalibacterium prausnitzii was previously recognized for its intestinal anti-inflammatory activities and it has been shown less abundant in patients with chronic intestinal diseases. However, the main problems encountered in the use of this…
Read More...
Read More...