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Shin-Etsu
Stability-Enhanced Ternary Solid Dispersions with HPMC and Soluplus
24. September 2017
Abstract
The aim of this study was to evaluate a novel combination of hydroxypropyl methylcellulose phthalate (HPMCP-HP-50) and Soluplus®polymers for enhanced physicochemical stability and solubility of the produced amorphous solid dispersions (ASDs). This was…
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Spray drying ternary amorphous solid dispersions of ibuprofen
31. August 2017
Abstract
A design of experiment (DoE) approach was used to investigate the critical formulation and processing parameters in spray drying ternary amorphous solid dispersions (ASDs) of ibuprofen. A range of 16 formulations of ibuprofen, HPMCP-HP55 and…
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Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into…
19. April 2017
Abstract
We developed a step-by-step experimental protocol using differential scanning calorimetry (DSC), dynamic vapour sorption (DVS), polarized light microscopy (PLM) and a small-scale dissolution apparatus (μDISS Profiler) to investigate the mechanism (solid-to-solid…
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A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability
02. March 2017
Zidovudine (AZT) mucoadhesive solid dispersions (SD) were prepared using a sodium starch glycolate (SSG) and hypromellose phthalate (HPMCP) mixtures as carrier to enhance the intestinal permeability and bioavailability of zidovudine. SDs were prepared using…
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New Multi-Particle Systems for Colon-Targeted Meloxicam
31. May 2016
Meloxicam (MLX) is a non-steroidal anti-inflammatory drug (NSAIDs) from the Oxicam family. This group of NSAIDs has been highly used in the treatment of rheumatoid arthritis and post-operative inflammation and is known as good antioxidants. Recently, their…
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Modifying release characteristics from 3D printed drug-eluting products
20. March 2016
This work describes an approach to modify the release of active compound from a 3D printed model drug product geometry intended for flexible dosing and precision medication. The production of novel polylactic acid and hydroxypropyl methylcellulose based feed materials…
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