Browsing Category
Shin-Etsu
Effect of Physical Properties and Chemical Substitution of Excipient on Compaction and…
As final attributes of dosage form largely depend on the properties of excipients used, understanding the effect of physicochemical properties of excipients is important. In the present study, six grades of L-HPC with varying degrees of particle size and hydroxypropyl content and the influence of…
Read More...
Read More...
Orodispersible Films: A Delivery Platform for Solid Lipid Nanoparticles?
To overcome the poor bioavailability observed for many newly developed active pharmaceutical ingredients (APIs), an appropriate formulation strategy is necessary. One approach is the formulation of these substances in solid lipid nanoparticles and their further processing into solid dosage forms. A…
Read More...
Read More...
Investigating the Role of Excipients on the Physical Stability of Directly Compressed Tablets
Stability studies are an integral part of the drug development process for any drug product. In addition to monitoring chemical degradation, the physical stability of a drug product must also be evaluated to ensure that the drug release and performance is not affected by storage. In this study,…
Read More...
Read More...
Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through…
Itraconazole (ITZ) is a class II drug according to the biopharmaceutical classification system. Its solubility is pH 3-dependent, and it is poorly water-soluble. Its pKa is 3.7, which makes it a weak base drug. The aim of this study was to prepare solid dispersion (SD) pellets to enhance the release…
Read More...
Read More...
Control Strategy for Process Development of High-Shear Wet Granulation and Roller Compaction to…
In this study, we developed a control strategy for a drug product prepared by high-shear wet granulation and roller compaction using integrated quality by design (QbD). During the first and second stages, we optimized the process parameters through the design of experiments and identified the…
Read More...
Read More...
Quantification of Compatibility Between Polymeric Excipients and Atenolol Using Principal Component…
An important challenge to overcome in the solid dosage forms technology is the selection of the most biopharmaceutically efficient polymeric excipients. The excipients can be selected, among others, by compatibility studies since incompatibilities between ingredients of the drug formulations…
Read More...
Read More...
Clinical Demonstrations of Controlled-Release Tablets Constructed by the Combined Usage of Shellac…
A new tablet system was examined for an intestinal delivery system using hydroxypropyl methylcellulose (HPMC) and shellac. HPMC was incorporated into the inside of the tablet, and shellac was coated on the surface, which was evaluated for its controlled-release property through several dissolution…
Read More...
Read More...
Data-Enriched Edible Pharmaceuticals (DEEP) with Bespoke Design, Dose and Drug Release
Data-enriched edible pharmaceuticals (DEEP) is an approach to obtain personalized medicine, in terms of flexible and precise drug doses, while at the same time containing data, embedded in quick response (QR) codes at a single dosage unit level. The aim of this study was to fabricate DEEP with a…
Read More...
Read More...
Impact of co-administered stabilizers on the biopharmaceutical performance of regorafenib amorphous…
Poor solubility of drug candidates is a well-known and thoroughly studied challenge in the development of oral dosage forms. One important approach to tackle this challenge is the formulation as an amorphous solid dispersion (ASD). To reach the desired biopharmaceutical improvement a high…
Read More...
Read More...
Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of…
The solution behavior and membrane transport of multidrug formulations were herein investigated in a biorelevant medium simulating fasted conditions. Amorphous multidrug formulations were prepared by the solvent evaporation method. Combinations of atazanavir (ATV) and ritonavir (RTV) and felodipine…
Read More...
Read More...