Determining the minimum amount of Kollidon® SR required in a tableting blend to obtain a matrix tablet
Kollidon® SR-based matrix formulations are well known for obtaining strong sustained release functionality. Depending on the solubility of the active ingredient and the required dissolution profile, pore formers need to be added for adjusting drug release.
This work was to investigate the maximum amount of excipients that can be added to PVAc still leading a ‘non disintegrating’ tablet matrix in the dissolution test. Three filling materials were tested, representing the groups of ‘stone like’, swellable and soluble excipients or actives.
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