Pharma Excipients
Sustained Release Agent
Formulation and Evaluation of Eudragit® RL Polymeric Double Layer Films for Prolonged-Release…
Transdermal drug delivery systems (TDDSs) were developed for prolonged tamsulosin (TMS) delivery. Double layer (DL) TDDSs were prepared using Eudragit® RL by conventional film-forming. Ethylene-vinyl acetate was used as the backing layer, triethylcitrate as plasticizer, and Capmul® PG-8-70 NF and…
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Application of electrostatic dry powder coating technology on capsules to achieve sustained release
This study introduces an electrostatic dry powder coating process to coat hard gelatin capsules and hydroxypropyl methylcellulose capsules directly in a coating pan to achieve sustained release. The process overcomes many difficulties in the capsule liquid coating process, such as stickiness and…
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Lipid nanocapsules for intracellular delivery of microRNA: A first step towards intervertebral disc…
Approximately 40% of cases of lower back pain are caused by disc degeneration disease (DDD). It is well established that microRNA (miR) dysregulation is a key player in various diseases, and its impact on DDD has recently been highlighted. RNAi (miR in particular) is increasingly being considered as…
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Formulation of sustain release matrix tablet of anti-anginal drug based on Eudragit L 100-55:…
This study aims to design and evaluate oral sustained release matrix tablets of BCS class 2 anti-anginal drug using Eudragit L 100-55 as the retardant polymer and mannitol as a channeling agent for the delivery of anti-anginal drug as twice-daily dose. The tablets were made using the traditional wet…
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3D-printed reservoir-type implants containing poly(lactic acid)/poly(caprolactone) porous membranes…
Implantable drug delivery systems are an interesting alternative to conventional drug delivery systems to achieve local or systemic drug delivery. In this work, we investigated the potential of fused-deposition modelling to prepare reservoir-type implantable devices for sustained drug delivery. An…
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Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both…
Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on β-CD unit under cryogenic conditions were reported for the…
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Gastroretentive Sustained-Release Tablets Combined with a Solid Self-Micro-Emulsifying Drug Delivery…
Gastroretentive drug delivery systems (GRDDS) get retained in the stomach for a long time, thus facilitating the absorption of drugs in the upper gastrointestinal tract. However, drugs that are difficult to dissolve or unstable in an acidic environment are not suitable for GRDDS. The current study…
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Exorbitant Drug Loading of Metformin and Sitagliptin in Mucoadhesive Buccal Tablet: In Vitro and In…
The aim of the proposed study is to develop a mucoadhesive buccal delivery system for the sustained delivery of metformin (MET) and sitagliptin (SIT) against diabetes mellitus (DM) with improved bioavailability. Polymeric blend of Carbopol® 940 (CP), agarose (AG) or polyvinylpyrrolidone K30 (PVP) as…
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Fluid properties and phase transition of antimicrobial eudragit RS/clove oil in situ forming depot
In situ forming depot (ISD) is a liquid drug delivery formulation generating solid depot after injection via a syringe into the body. The 5% w/w doxycycline hyclate (DH)-incorporated poly (ethyl acrylate, methyl methacrylate, trimethylammonioethyl methacrylate chloride) (Eudragit RS) ISD systems…
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Fabrication of three-dimensional-printed ofloxacin gastric floating sustained-release tablets with…
The objective of this study was to develop a novel ofloxacin gastric floating system with different internal structures by paste extrusion printing and to explore the relationship between tablets with different structures and the release behavior and floating time. The gastric floating sustained…
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