Pharma Excipients
Sustained Release Agent
Development of Sustained Release Eudragit Based Matrix Tablet of Fluvastatin Sodium Microspheres
The purpose of this research is to investigate the suitability of acquiring improved dissolution profile and sustained release of Fluvastatin sodium to reduce dosage frequency via a novel combination of freeze dried microspheres and Eudragit polymers-based matrix tablet technologies. Fluvastatin…
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Biphasic Drug Release from Rolled-Up Gelatin Capsules with a Cylindrical Cavity
Biphasic drug delivery systems are used for quick release of a specific amount of drug for immediate amelioration of a patient’s state, followed by sustained release, to avoid repeated administration. This type of delivery is often necessary for pain management and the treatment of many pathologies,…
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Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded…
Local delivery of drug is a promising strategy to manage periodontitis characterized by chronic inflammation of the soft tissue surrounding the teeth. An optimized system should prolong the drug retention time and exhibit controlled drug permeation through the buccal mucosal layer. This study was…
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Spray layering of human immunoglobulin G: Optimization of formulation and process parameters
Spray layering is a technique used to apply drug or functional polymers onto carrier beads; in addition, it can be used as an alternative method for protein drying and to layer protein on a multiparticulate delivery system. In this study, the effects of formulation variables and process parameters…
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Development and in-vitro in-vivo characterization of in-situ gelling sustained-release nevirapine…
Nevirapine is a BCS class-II drug used in the treatment and prevention of HIV/AIDS, specifically HIV-1. This study was aimed to develop and evaluate a novel pH-responsive in-situ gelling sustained-release nevirapine pediatric suspension (SRNPS) for treatment and prevention of mother-to-child…
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Formulation, characterization, optimization and in-vivo evaluation of methazolamide liposomal…
The rationale of this study was to formulate topically effective sustained release ophthalmic Methazolamide (MTA) liposomal in-situ gel. Lipid film hydration method was employed for the preparation of MTA liposomes consisting of lecithin and cholesterol. Optimization of the MTA liposomes by…
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Sustained-release capsules coated via thermoforming techniques
Capsule coatings have a wide range of applications as they afford protection to active pharmaceutical ingredients. However, few studies have focused on capsule coating owing to the sensitivity of hard gelatin shells to solvents and high temperature. In the present study, we aimed to coat capsules…
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Development of a Scalable Process of Film-Coated bi-Layer Tablet Containing Sustained-Release…
The development of new drugs that combine active ingredients for the treatment hypertension is critically essential owing to its offering advantages for both patients and manufacturers. In this study, for the first time, detailed development of a scalable process of film-coated bi-layer tablets…
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Development of Glimepiride Loaded Sustained Release Microparticles Using Tubular Microreactor
Background: Glimepiride is a third-generation, oral anti-diabetic sulfonylurea drug, generally recommended for the treatment of type–II diabetes. A biocompatible polymer, Eudragit RS 100 is widely used for the preparation of targeted and time-controlled release of drugs. Glimepiride is encapsulated…
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Injection-molded capsule bodies and caps based on polymer blends for controlled drug delivery
A variety of polymer:polymer blends was used to prepare hot melt extrudates and empty capsules (bodies and caps) by injection molding using a benchtop extruder (Babyplast). Kollidon SR:inulin and Carbothane:inulin blends were investigated. The impact of the blend ratio on the water uptake and dry…
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