Sustained Release Agent

The present study aimed to develop carvedilol (CAR)-loaded (25% w/w) sustained release solid dispersion (SRSD), for enhanced dissolution and to explore the applicability of different industrially accessible drying techniques. Methods SRSD-CAR containing different ratios of polymers were prepared…
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Tablet film coating is a common but critical process providing various functionalities to tablets, thereby meeting diverse clinical needs and increasing the value of oral solid dosage forms. Tablet film coating is a technology-driven process and the evolution of coated dosage forms relies on…
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Objectives The aim of this study was to investigate the influence of in vitro release test parameters on the release of ibuprofen from sustained release inert matrix tablets. Materials and methods Ibuprofen sustained release inert matrix tablets were manufactured at a laboratory scale using…
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Although dissolving microneedles have garnered considerable attention as transdermal delivery tools, insufficient drug loading remains a challenge owing to their small dimension. Herein, we report a one-step process of synthesizing semi-dissolving microneedle (SDMN) patches that enable effective…
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Diclofenac sodium was used as a model drug for preparation of delayed-release (DR) multiparticulates, which were further processed into solid oral dosage forms such as capsules and tablets. Multiple unit pellets systems (MUPS) were prepared from different types of starter pellets (inert cores)…
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The short half-life and bitter taste of carbinoxamine maleate (CAM) lead to poor compliance by pediatric patients who are being treated for allergic rhinitis. To address these issues, carbinoxamine-resin complexes (CRCs) were prepared by ion exchange and then coated with Kollicoat SR 30D. The…
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by Priya Poduval | July 22, 2020 Solubilizing SR excipients are difficult unless solvents are used for cleaning. Most of the companies using this method have a similar cleaning process – manual application using a lint-free wipe followed by vigorous scrubbing. Although this is effective, it is…
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Flurbiprofen (FBP) is an ibuprofen derivative with less gastric side effects and short biological half-life (4.7–5.7 h). The study aimed to formulate FBP as a sustained-release pellets by extrusion/spheronization to overcome its short half-life and to decrease dose frequency. The wet mass of the…
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The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it dicult to achieve therapeutic levels…
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Highlights Novel hydrogel-forming microneedles were produced. Their physicochemical properties were promising. Methotrexate was successfully delivered in vitro and in vivo. Methotrexate (MTX) is one of the mainstays of treatment for rheumatoid arthritis (RA) and juvenile idiopathic…
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