Pharma Excipients
Sustained Release Agent
Lipid Based Excipients for Modified Release
Modified- or sustained-release matrices are designed to release a drug slowly over an extended period of time. Formulations must be robust to ensure drug release over time and avoid dose-dumping. Lipid-based matrices are water-insoluble and do not swell or erode when in contact with aqueous media.…
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Sustained release – made from nature with Tylopur Xtend Nutra®
XTENDED RELEASE OF ACTIVE INGREDIENTS FOR NUTRACEUTICAL & NUTRITIONAL APPLICATIONS
Tylopur Xtend Nutra® is a plant derived cellulose-based ingredient produced by Shin-Etsu. It is specifically developed for nutraceutical and nutritional applications. It enables xtended release of…
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Quality by Design thinking in the development of long-acting injectable PLGA/PLA-based microspheres…
Adopting the Quality by Design (QbD) approach in the drug development process has transformed from ‘nice-to-do’ into a crucial and required part of the development, ensuring the quality of pharmaceutical products throughout their whole life cycle. This review is discussing the implementation of the…
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Easy to Swallow “Instant” Jelly Formulations for Sustained Release Gliclazide Delivery
It is a challenge to safely administer sustained release medicines to patients with dysphagia. Sustained release tablets must not be crushed and multiparticulates with large particle sizes cause gritiness reducing patient acceptability. The aim of this study was to develop “instant” jellies as…
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A dual pH and microbiota-triggered coating (PhloralTM) for fail-safe colonic drug release
Enteric-coated dosage forms are widely used for targeting the ileo-colonic region of the gastrointestinal (GI) tract. However, accurate targeting is challenging due to intra- and inter-individual variability in intestinal paramaters such as fluid pH and transit times which occasionally lead to…
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Moxifloxacin Hydrochloride-Loaded Eudragit® RL 100 and Kollidon® SR Based Nanoparticles:…
Background: Considering the low ocular bioavailability of conventional formulations used for ocular bacterial infection treatment, there’s a need for designing efficient novel drug delivery systems that may enhance of precorneal retention time and corneal permeability.
Aim and Objective: The…
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A tunable extruded 3D printing platform using thermo-sensitive pastes
Extruded 3D printing is emerging as an attractive fabrication technology in the field of personalized oral medicines. The objective of this study was to develop a tunable extruded 3D printing platform based on thermo-sensitive gelatin pastes to meet the needs of achieving different drug release…
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Static and dynamic structural features of single pellets determine the release behaviors of…
The multiple-unit sustained-release (MUSR) dosage forms containing numerous sustained-release subunits present a reliable choice for oral formulation of controlled release systems. As a typical MUSR, the metoprolol succinate sustained-release tablet is an advanced system with limited researches…
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Localized Delivery of Ibuprofen via a Bilayer Delivery System (BiLDS) for Supraspinatus Tendon…
The high prevalence of tendon re‐tear following rotator cuff repair motivates the development of new therapeutics to promote improved tendon healing. Controlled delivery of non‐steroidal anti‐inflammatory drugs (NSAIDs) to the repair site via an implanted scaffold is a promising option for…
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PLGA Microspheres with Alginate-Coated Large Pores for the Formulation of an Injectable Depot of…
As the main symptom of Alzheimer’s disease-related dementia is memory loss, patient compliance for donepezil hydrochloride (donepezil), administered as once-daily oral formulations, is poor. Thus, we aimed to design poly(lactic-co-glycolic acid) (PLGA) microspheres (MS) with alginate-coated large…
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