Sustained Release Agent

Ketoprofen granules were prepared by a relatively newer method, namely surfactant-assisted wet granulation (SAWG) approach using different concentrations (1-5%) of Soluplus®, polyethylene glycol (PEG) 6000, PEG 4000, poloxamers L6200 and L3100. The developed granule formulations were characterized…
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In this study, gastro-retentive porous floating tablets of captopril based on zein are reported using l-menthol as a porogen. Tablets were prepared by the direct compression method. Removing of l-menthol through sublimation process generate pores in tablets, which decrease the density to promote…
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Compritol® 888 ATO is a fine white powder, insoluble in water and organic solvents. It has no odor and no taste. It is used as lubricant, coating agent for the protection of sensitive drugs, in taste masking and as a matrix former in sustained release. Compritol® 888 ATO is an ester of mono-,…
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What is a Tab-in-Tab as a pharmaceutical dosage form? Only few articles about Tab-in-Tab pharmaceutical dosage forms can be found and specific tableting equipment is needed for such. It can be interesting as a novel approach for sustained release applications. Dr. Karim Maarif from KMCD has put…
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Compritol® 888 ATO combines several advantages when used as a sustained release matrix agent. These will be explained and illustrated throughout this Guideline. Download Gattefossé guidelines and get practical tips for successful formulation of sustain release tablets with Compritol® 888 ATO -…
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Polymer-based long-acting matrix tablets are often used to ensure patient compli- ance and API efficacy of orally applied drugs. Increasingly, polyvinyl alcohols (PVAs) are used as hydrophilic, swellable and erodible matrices in such sustained release (SR) tablets, as they show a prolonged API…
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In pharmaceutical formulations, polymers are traditionally and commonly used as viscosifier, binder, gelling agent, suspending agent, protective agent, controlled-release medium, adhesive, and packaging material. With the development of the abuse-deterrent formulations in recent years, a new…
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The aim of this work was to develop a mathematical model to estimate the drug release from a conventional single-compartment reservoir pellet and extend its applicability to multi-compartment reservoir pellets. Conventional pellets were prepared by layering the drug onto starter-core then applying…
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A design of experiments (DOE) approach (2-level full factorial design) was used to investigate the effect of several formulation and process variables on the properties of fast disintegrating tablets comprising starch-based pellets and excipient granules and to optimize and validate the design…
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In the study, we developed a novel oral dosage form of Compound Danshen to resolve the problems of low bioavailability, disequilibrium in drug release, and stomach degradation of active components of Compound Danshen in conventional formulas. A colon-specific osmotic pump capsule (COPC) of…
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