Pharma Excipients
Sustained Release Agent
Formulation and evaluation of new oxycodone extended release multiple unit pellet system
The goal of the present study is to prepare a stable, multiple-unit, extended-release dosage form containing oxycodone pellets coated with aqueous ethylcellulose (EC) dispersion, Surelease E-7-19050. The application of 18% w/w of EC leads to the similar drug release with the hydrophobic,…
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Sustained Release Ziprasidone Microparticles Prepared by Spray Drying with Soluplus® and Ethyl…
The purpose of this study was to develop and evaluate a new formulation of ziprasidone (ZIP) for improved fasted state absorption and sustained drug release.
ZIP solid dispersions were produced via spray drying using Soluplus®, an amphiphilic polymer, as the solubility enhancer. Physicochemical…
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Evaluation of Lipophilic Properties of Thermoplastic Granule in Formulation of Sustained Release…
This study was aimed at developing a new, technically simple method for the preparation of a once-daily sustained release matrix formulations, which would enable reproducible release of the active ingredient.
Thermoplastic granulation is a new technique in pharmaceutical formulation. Coated…
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Development of dual–release pellets of the non-steroidal anti–inflammatory drug celecoxib
In the current study, once-a-day dual-release pellets of the selective non-steroidal anti-inflammatory drug celecoxib (200 mg) was developed to treat arthritis.
Pellets were prepared where a 100 mg celecoxib, located in the outer layer, was released in an immediate-release (IR) pattern, whereas…
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Optimization and characterization of novel sustained release supermicro-pellet based dry suspensions…
Traditional dosage forms of dexibuprofen extremely limit their clinical applications because of the bitter taste and the frequent drug administration caused by the relatively short half-life of the drug.
This study aims to design novel sustained release (SR) supermicro-pellet based dry…
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Nano-crystalline cellulose: Preparation, modification and usage as sustained release drug delivery…
Nano crystalline cellulose (NCC) has gained attention in the pharmaceutical industry owing to its biodegradable nature and high mechanical properties.
In the present work we reported preparation of NCC from cellulose isolated from a bio-waste, its modification and exploration as drug delivery…
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Neem gum based pH responsive hydrogel matrix: A new pharmaceutical excipient for the sustained…
The present research work was aimed to synthesize neem gum-based site-specific drug delivery device for anticancer drug methotrexate at different pH condition.
The hydrogel-based drug delivery device was synthesized by optimizing reaction parameters using a factorial design approach response…
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Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral…
Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging.
The aim…
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Polyvinyl alcohol boric acid – A promising tool for the development of sustained release drug…
The paper deals with the design and investigation of the morphology, in vitro drug release and biocompatibility of some new formulations based on polyvinyl alcohol boric acid (PVAB) and diclofenac sodium salt (DCF), with the aim to explore the ability of PVAB to act as a matrix for controlled drug…
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Prilling of API/fatty acid suspensions: processability and characterisation
Current study evaluated the processability and characteristics of prills made of an active pharmaceutical ingredient/fatty acid (API/FA) suspension instead of previously studied API/FA solutions to enlarge the application field of prilling.
Metformin hydrochloride (MET) and paracetamol (PAR) were…
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