Sustained Release Agent

Despite substantial advancements in divergent drug delivery systems (DDS), there is still room for novel and innovative nanoparticle-mediated drug delivery methodologies such as core/shell liposomes to deliver drugs in a kinetically controlled manner into the active site without any side effects.…
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Modified release of furosemide from tablet formulations is preferred by patients, because of physiological problems, acute diuresis being the most serious, compared to the forms designed for immediate release. With this in view, we aimed at achieving furosemide’s longer gastric retention and…
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In recent years mesoporous silica is gaining attention because of their emerging applications in drug delivery. Since their first appearance in materials science in the 1990s, these inorganic carriers have been successfully used in other areas such as catalysis, purification, and adsorption. The…
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Furosemide, a chloride channel blocker ordinarily used as a high-ceiling or loop diuretic, is practically insoluble in water and dilute acids. Due to its acidic nature, furosemide is mostly absorbed in the stomach and in the upper small intestine. Efforts have focused on the development of sustained…
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Aim: The sustained release tablets of Aceclofenac were prepared and evaluated for the sustained release drug profile with an aim to reduce dosing frequency and provide patient compliance. Materials and Method: The tablets were prepared by using different percentages of Kollidon SR, Carbopol 934P…
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Polyvinylpyrrolidone includes soluble and insoluble grades; soluble grades are synthesised by the mechanism of polymerization, the free radical polymerization into water by using hydrogen peroxide as an initiator, the mechanism which terminates the polymerisation reaction makes it probable to…
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POLYOX™ resins are nonionic poly (ethylene oxide) polymers. They are white to off-white, free-flowing hydrophilic powders supplied in a wide variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. POLYOX™ polymers possess thermoplastic…
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Film tablets are a common oral dosage form. For many of the functions film layers can have on pharmaceutical tablets, a high degree of coating uniformity is required. In studies on coating uniformity the coefficient of variation is commonly used as a marker. Previous studies regarding the trend…
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Kollidon® SR-based matrix formulations are well known for obtaining strong sustained release functionality. Depending on the solubility of the active ingredient and the required dissolution profile, pore formers need to be added for adjusting drug release. This work was to investigate the maximum…
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Dr. Rainer Dobrawa talks about some current trends in instant- and modified-release formulations at a BASF symposium in Ludwigshafen, Germany. https://www.youtube.com/watch?v=aazDrkIcsX8&feature=youtu.be More on BASF PHarmaceutical EXCIPIENTS
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