Pharma Excipients
Sustained Release Agent
Multi-dose oral abuse deterrent formulation of Loperamide using Hot melt extrusion
Loperamide, an over the counter anti-diarrheal drug, also infamously referred to as “poor man's methadone”.
Due to the ease of availability and low price, people/patients abuse it by consuming more than 30 tablets to achieve euphoric effect and to combat opioid withdrawal. But supratherapeutic…
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Novel lipid-based drug delivery systems containing polymethacrylate polymers as solid carriers for…
Formulation of lipid-based drug delivery systems is recognized as a promising strategy to increase bioavailability of simvastatin (SV).
The purpose of this study was to formulate advantageous lipid-based drug delivery systems for pH-controlled release of SV using polymethacrylate polymers…
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Oromucosal films: From patient centricity to production by printing techniques
Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift…
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Development and evaluation of synchronized and sustained release Tripergium Wilfordii tablets based…
Development of synchronized and sustained release preparations for herbal medicines is still a vast challenge due to their complicated components with different physicochemical properties.
In this study, tablets were developed to achieve synchronized and sustained release of the multi-components…
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Comparison of the coating process and in vitro dissolution of 3 mm gastro-resistant minitablets and…
Minitablets are solid oral forms, which, due to their size (1-3 mm), may be easily swallowed by children.
The administration of minitablets in a certain number of units allows for flexible dosing for a broad age group of paediatric patients, which is particularly important for modified-release…
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Enteric coating of oral solid dosage forms as a tool to improve drug bioavailability
Enteric coating is a common procedure in the development of oral pharmaceutical dosage forms.
The main advantage of enteric coating is that it protects the drug from acidic pH and enzymatic degradation in the stomach while protecting it from the undesirable effects of some drugs. There is certain…
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Water-insoluble polymers as binders for pellet drug layering: Effect on drug release and performance…
The objective of this study was to investigate the applicability of water-insoluble polymers as binders for pellets drug layering to extend the drug release.
Carbamazepine was layered on sugar cores in fluidized bed coater using isopropanol (IPA):water solution or aqueous dispersion of…
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Huperzine a loaded multiparticulate disintegrating tablet
Huperzine A loaded multiparticulate tablet with sustained release was developed to reduce dosing frequency and increase swallowing.
The sustained release was provided by the ethyl cellulose/Poloxamer 127 (EC/F127) microparticles (MPs). F127 was added to facilitate drug release of EC MPs, and the…
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Screening of different polysaccharides in a composite film based on Eudragit RS for subsequent use…
This study aims at identifying the more suitable polysaccharide in a composite film based on Eudragit RS for 5-ASA delivery to the colon.
Different polysaccharides (pectin, chitosan, guar, inulin, and dextran) were examined. The mechanical properties, swelling index, loss of film mass and…
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Enhancing sustained drug release property of chitosan
Chitosan has not been able to be formulated as sustained-release crosslinked/coacervated drug carrier in the form of spheroids prepared by extrusion-spheronisation technique.
This study re-visits chitosan spheroids and their drug (water-soluble chlorpheniramine maleate) release profiles as a…
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