Pharma Excipients
Sustained Release Agent
Blend of cellulose ester and enteric polymers for delayed and enteric coating of core tablets of…
The focus of this work was to explore feasibility of using blends of cellulose esters (CA 320S, CA 3980-10 or CAB 171-15) and enteric polymers (C-A-P, Eudragit® L100 or HPMCP HP-55) for delayed and enteric coating of tablets containing either diclofenac sodium (DFS, high dose) or prednisone (PDS,…
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Delivery of Poorly Soluble Drugs via Mesoporous Silica: Impact of Drug Overloading on Release and…
The most important properties of promising drug candidates for oral dosage form are aqueous solubility and intestinal permeability. Over 40% of drugs on the market are BCS class II and IV, which have low solubility. Furthermore, new chemical entities are even less soluble compared to marketed…
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Novel Hot Melt Extruded Matrices of Hydroxypropyl Cellulose and Amorphous Felodipine–Plasticized…
Hydroxypropyl methylcellulose (HPMC) is a hydrophilic retarding-release polymer with the limited application in hot melt extrusion (HME) due to its high glass transition temperature (Tg181–191°C) and melt viscosity.
The aim of this study is to develop hot melt extruded matrices using…
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Development and evaluation of an omeprazole-based delayed-release liquid oral dosage form
Modified-release oral dosage forms are commonly used in pharmaceutics to delay or sustain the release of drugs. Nowadays, they are only marketed as solid dosage forms such as capsules or tablets.
Therefore, the development of a liquid oral dosage form with modified-release properties has been…
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Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery
The potential of the polyampholytic and polyelectrolytic starch compounds as excipients for drug controlled release was investigated using various tracers differing in terms of solubility and permeability.
Ampholytic trimethylaminecarboxymethylstarch (TMACMS) simultaneously carrying…
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Thermoplastic polyurethane as matrix forming excipient using direct and ultrasound-assisted…
Thermoplastic polyurethanes (TPU) are block copolymers utilized in a wide variety of applications due to their superior characteristics as resistance, flexibility and biocompatibility. However, the use of TPU as a matrix tablet forming excipient is more limited.
For the first time, matrix tablets…
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Hot-melt extrusion in the pharmaceutical industry: toward filing a new drug application
The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where thermodynamics, polymer screening, multivariate statistics and process optimization are combined, to increase the success of…
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Controlled release tablets based on HPMC:lactose blends
Hydroxypropyl methylcellulose (HPMC) is a frequently used matrix former for controlled release tablets. To adjust desired drug release kinetics, freely water-soluble lactose can be added.
The aim of this study was to investigate the importance of the type of preparation technique of propranolol…
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Correlation between the solid state of lipid coating and release profile of API from hot melt coated…
Solvent-free hot melt coating (HMC) provides a safer and more economic process compared to the conventional solvent coating techniques. However, drug release instability and the lack of fundamental understanding on it are limiting factors for application of HMC for industrial productions.
In this…
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A QCM-based assay of drug content in Eudragit RS 100-based delivery systems
A specific version of the quartz crystal microbalance method has been proposed for quantitative evaluation of drug content in polymeric drug carrier systems. In this study, ammonio methacrylate copolymer (type B) microparticles and their standard solutions have been prepared and loaded with set…
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