Pharma Excipients
Sustained Release Agent
Development of a novel method utilising dissolution imaging for the measurement of swelling…
A variety of imaging techniques are currently used within the field of pharmaceutics to help understand and determine a wide range of phenomena associated with drug release from hydrophilic matrix tablets.
This work for the first time aims at developing an appropriate testing imaging methodology…
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Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems
Particle engineering has become a hot topic in the field of modified-release delivery systems during last decades. It has a wide range of pharmaceutical applications and is a bridge linking between drugs and drug delivery systems.
Particles are an important part of many dosage forms and viewed as…
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Adjustment of triple shellac coating for precise release of bioactive substances with different…
Formulations for the controlled release of substances in the human terminal ileum and colon are essential to target the gut microbiome and its interactions with the intestinal mucosa. In contrast to pharmaceutical enteric coatings, reliable food-grade alternatives are still scarce.
Shellac…
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Characterization of Amorphous Solid Dispersion of Pharmaceutical Compound with pH-Dependent…
A continuous-spray granulator (CTS-SGR) is a one-step granulation technology capable of using solutions or suspensions.
The present research objectives were, (1) to reduce the manufacturing operations for solid dosage formulations, (2) to make amorphous solid dispersion (ASD) granules without…
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Evaluation of Hydrogenated Soybean Phosphatidylcholine Matrices Prepared by Hot Melt Extrusion for…
The aims of this study were to prepare hydrogenated soybean phosphatidylcholine (HSPC) matrices by hot melt extrusion and to evaluate resulting matrix potential to extend drug release in regard to drug loading and solubility for oral drug delivery of water-soluble drugs.
The liquid crystalline…
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Statistical optimization of alginate-based oral dosage form of 5-aminosalicylic acid aimed to…
Although different colon-targeting methods such as pH and time-dependent as well as bacterially degradable systems have been developed, due to variations in physiological conditions of patients, one system alone cannot produce a reliable drug delivery system.
Therefore, in this study, an attempt…
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Modelling the Effect of Process Parameters on the Wet Extrusion and Spheronisation of High-Loaded…
The aim of the present study was to develop an alternative process to spray granulation in order to prepare high loaded spherical nicotinamide (NAM) pellets by wet extrusion and spheronisation. Therefore, a quality by design approach was implemented to model the effect of the process parameters of…
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Adhesive alginate for buccal delivery in aphthous stomatitis
Recurrent aphthous stomatitis being the most common chronic disease of the oral cavity affects 5–25% of the population.
Aim
This study goals to develop a novel polymeric excipient based on alginate with enhanced mucoadhesion and controlled release for buccal therapy of aphthae.
Methods…
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Electrospun nanofibers for customized drug-delivery systems
Nanofiber-based drug-delivery systems are widely applicable for specific drug release, according to the target location and timing, to achieve the desired therapeutic effects. A nanofiber formulation is usually developed for a specific drug, and a change of drug can drastically affect the release…
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Characterization and evaluation of different mesoporous silica kinds as carriers for the development…
This work evaluated the suitability of various mesoporous silicas as carriers for developing an oral formulation endowed with improved dissolution properties of glibenclamide, hypoglycemic agent poorly water-soluble.
The different silicas were examined for solid-state, morphology, and…
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