Sustained Release Agent

Nifedipine and nicardipine loaded PLGA extrudates have a great potential to prevent cerebral vasospasms after subarachnoid hemorrhage or surgical clipping of aneurysm. A constant release over approx. two weeks is desired. Although in vivo studies on humans have been reported, there is limited…
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Nowadays, probiotic bacteria are extensively used as health-related components in novel foods with the aim of added-value for the food industry. Ingested probiotic bacteria must resist gastrointestinal exposure, the food matrix, and storage conditions. The recommended methodology for bacteria…
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At this year's 10th DDF Summit in Berlin, Fred Monsuur from GRACE held a presentation on Mesoporous Silica DDS - An Option for Liquisolid Drug Delivery Systems. Did you miss the event and or want to have a look at the slides again? We enable you to see the full presentation. Have a look at our…
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Due to the additional particle coalescence in the coating, changes in the dissolution profile occur over time in the formulations coated by aqueous ethylcellulose latex. Dry thermal treatment (DT) of the coating can be used as a prevention of this process. Alternatively, it is advisable to take…
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The present investigation was conducted to formulate and evaluate gastric-floating controlled release tablets of Ginkgolides. The target tablets were formulated by powder direct compression method combined with hydrophilic polymer, floating assistant agent, and effervescent substance. Formulations…
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in this video you discover how dual matrix containing two sustained release(SR) agents, Compritol® 888 ATO and HPMC enables the production of robust SR tablets. With dual matrix, you can: reduce the SR agent concentration reduce the alcohol quantity used in wet granulation process…
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To face the challenges of oral delivery of peptide and protein drugs (P/P drugs), self-emulsifying drug delivery systems (SEDDSs) containing monoacyl phosphatidylcholine (MAPC), Labrasol (LAB) and medium-chain (MC) monoglycerides as permeation enhancers (PEs) were evaluated for their effect on…
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The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus (HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to design a supersaturated self-microemulsifying drug delivery…
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To improve the dissolution and oral bioavailability of valsartan (VST), we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMED) composed of Capmul® MCM (oil), Tween® 80 (surfactant), Transcutol® P (cosurfactant), and Poloxamer 407 (precipitation inhibitor) but…
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The purpose of the study was to develop sustained release tablets containing bisoprolol fumarate and an innovative combination of Precirol ATO5 and hydroxypropyl methylcellulose, in order to conclude upon: properties of pharmaceutical tablet formulations, drug-excipients interactions, evaluate their…
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