Pharma Excipients
Sustained Release Agent
Understanding the release performance of pellets with hydrophobic inclusions in sustained-release…
The aim of this study was to evaluate how the addition of hydrophobic inclusions to sustained-release pellet film coat can affect drug release. Sustained-release formulations, in particular multiparticulate systems are gaining popularity because they are able to reduce the dosing frequency of drugs…
Read More...
Read More...
Production of dry-state ketoprofen-encapsulated PMMA NPs by coupling micromixer-assisted…
We present a two-step process to produce dry-state Ketoprofen-loaded poly(methyl methacrylate) nanoparticles (NPs) with controllable size and tunable drug release profile. A colloidal suspension of drug-loaded nanoparticles was first obtained from a nanoprecipitation process and then transferred…
Read More...
Read More...
Can Drug Release Rate from Implants Be Tailored Using Poly(urethane) Mixtures?
Hydrophobic and hydrophilic thermoplastic poly(urethane) (TPU) mixtures offer the opportunity to tune water swelling capacity and diffusion rate for drugs exhibiting broadly different properties. We sought to (1) assess the range of drug diffusion rates achieved by varying hydrophilic-to-hydrophobic…
Read More...
Read More...
Printfills: 3D printed systems combining Fused Deposition Modeling and Injection Volume Filling.…
Three-dimensional printing has become a feasible manufacturing technique for pharmaceutical products providing cheap and accurate freeform systems with a great potential for personalized-dose drugs. Fused Deposition Modeling (FDM) highlights among other 3D technologies due to its low cost and easy…
Read More...
Read More...
Testosterone- and vitamin-grafted cellulose ethers for sustained release of camptothecin
Camptothecin (CPT), a potent anticancer drug with known antiviral activity, is halted of clinical use. Few drug delivery systems of CPT are approved for therapy. Hereby, we propose the encapsulation of hydrophobic CPT in the inner core of cellulose nanoaggregates for sustained release with retaining…
Read More...
Read More...
Conversion of PLGA nanoparticle suspensions into solid dosage forms via fluid bed granulation and…
Incorporating poorly soluble drugs into polymeric nanoparticles is a widely investigated approach to improve their biopharmaceutical performance. Poly(DL-lactide-co-glycolide) (PLGA) nanoparticle formulations have previously been tested and recommended as drug carriers for peroral administration of…
Read More...
Read More...
Excipients for Modified Release by Gattefossé
Modified- or sustained-release matrices are designed to release a drug slowly over an extended period of time. Formulations must be robust to ensure drug release over time and avoid dose-dumping. Lipid-based matrices are water-insoluble and do not swell or erode when in contact with aqueous media.…
Read More...
Read More...
Design of antiretroviral drug-polymeric nanoparticles laden buccal films for chronic HIV therapy in…
Anti-HIV drug Lamivudine exhibit shorter half-life (2 h) and poor bioavailability (62% in paediatric patients), multiple dosing is required. To overcome the limitations, nanoparticles loaded buccal film was developed for prolonged drug release and improved efficiency. Nanoprecipitated…
Read More...
Read More...
Designing pH-Responsive Biodegradable Polymer Coatings for Controlled Drug Release via Vapor-Based…
We present the design of a novel pH-responsive drug release system that is achieved by solventless encapsulation of drugs within a microporous membrane using a thin capping layer of biodegradable polymethacrylic anhydride (PMAH) coating. The coating was synthesized via a mild vapor polymerization…
Read More...
Read More...
Rheology of Cellulose Ether Excipients Designed for Hot Melt Extrusion
new family of cellulosic ether polymeric excipients has been recently engineered for fabrication of amorphous solid dispersions (ASDs) of active pharmaceutical ingredients (API) via hot-melt extrusion (HME). These hydroxypropyl methyl cellulose (HPMC) excipients enable plasticizer-free melt…
Read More...
Read More...