Pharma Excipients
Sustained Release Agent
Design, development and in vitro quantification of novel electrosprayed everolimus-loaded…
Everolimus (RAD001) a mammalian target of rapamycin has been hampered by poor solubility, affecting its dissolution rate, a relationship that extends to low bioavailability. Nanoparticles (NP) based on Soluplus (SOL®) and Polyvinyl alcohol (PVA) was fabricated by electrospraying (ES) for the…
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Quality by Design-Optimized Glycerosome-Enabled Nanosunscreen Gel of Rutin Hydrate
Sunburn is caused by prolonged exposure to ultraviolet (UV) rays from the sun, resulting in redness of the skin as well as tenderness, swelling, and blistering issues. During the healing process, it can cause peeling, irritation, and some long-term effects, including premature aging, pigmentation,…
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Comparing the Performance of Raman and Near-Infrared Imaging in the Prediction of the In Vitro…
In this work, the performance of two fast chemical imaging techniques, Raman and near-infrared (NIR) imaging is compared by utilizing these methods to predict the rate of drug release from sustained-release tablets. Sustained release is provided by adding hydroxypropyl methylcellulose (HPMC), as its…
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A starch-based implant as a controlled drug release system: Non-invasive in vivo characterization…
Solid implants are parenteral depot systems that can provide a controlled release of drugs in the desired body area over a few days to months. Finding an alternative for the two most commonly used polymers in the production of parenteral depot systems, namely Poly-(lactic acid) (PLA) and…
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An evaluation of microcrystalline cellulose attributes affecting compaction-induced pellet coat…
Pellet coat damage in multi-unit pellet system (MUPS) tablets has previously been studied and addressed with limited success. The effects of lactose filler material attributes on pellet coat damage have been relatively well-studied but a similar understanding of microcrystalline cellulose (MCC) is…
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Tip loaded cyclodextrin-carvedilol complexes microarray patches
Carvedilol, a β-blocker prescribed for chronic heart failure, suffers from poor bioavailability and rapid first pass metabolism when administered orally. Herein, we present the development of tip microarray patches (MAPs) composed of ternary cyclodextrin (CD) complexes of carvedilol for transdermal…
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Development of chitosan-graphene oxide blend nanoparticles for controlled flurbiprofen delivery
The use of natural polymeric nanoparticles (Nps) as drug carriers is a highly promising area of research in the field of drug delivery systems because of their high efficiency. In this study, flurbiprofen (FB) loaded chitosan-graphene oxide (CS-GO) blend Nps were synthesized as a controlled delivery…
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Optimization and Evaluation of Lisinopril Mucoadhesive Sustained Release Matrix Pellets: In-Vitro…
Lisinopril (LIS) it is antihypertensive drug, classified as a class III drug with a high water solubility and low permeability. To overcome the low permeability, 32 factorial designs aimed to formulate LIS as a sustained-release (LIS-SR) matrix pellet by extrusion/spheronization. Matrix pellets were…
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Microneedle array patches for sustained delivery of fluphenazine: A micron scale approach for the…
Schizophrenia is a severe chronic mental illness characterised by impaired emotional and cognitive functioning. To treat this condition, antipsychotics are available in limited dosage forms, mainly oral and injectable formulations. Although injectable antipsychotics were designed to enhance…
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Sustained Release of Salicylic Acid from Ethyl Cellulose Microspheres Fabricated Using…
Delivery of drugs using micro-sized particles is an efficient tool. Using ethyl cellulose (EC) as a polymer and the quasi-emulsion solvent diffusion (QESD) method paves the way for the utilization of a cost-effective polymer and an efficient fabrication method. Poly(vinyl alcohol) in water was used…
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