Pharma Excipients
Sustained Release Agent
Solid implantable devices for sustained drug delivery
Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug administration routes. Oral and injectable drug administration are the most common routes for drug delivery providing peaks of drug concentrations in blood after administration followed by concentration decay…
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Ultra-High-Resolution Optical Coherence Tomography for the investigation of thin multilayered…
Optical Coherence Tomography (OCT) has recently gained attention as a promising technology for in-line monitoring of pharmaceutical film-coating processes for (single-layered) tablet coatings and end-point detection with commercial systems. An increasing interest in the investigation of…
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Long-acting Parenteral Drug Delivery Systems for the Treatment of Chronic Diseases
Abstract
The management of chronic conditions often requires patients to take daily medication for an extended duration. However, the need for daily dosing can lead to nonadherence to the therapy, which can result in the recurrence of the disease. Long-acting parenteral drug delivery systems have…
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Long-acting PLGA microspheres: advances in excipient and product analysis toward improved product…
Abstract
Poly(lactic-co-glycolic acid) (PLGA) microspheres are a sustained-release drug delivery system with several successful commercial products used for the treatment of a variety of diseases. By utilizing PLGA polymers with different compositions, therapeutic agents can be released over…
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SEPISMART™ SR – Time to release your creativity
See the new Seppic product SEPISMART™ SR in use cases with Vitamin C and caffein delivery:
INTESTINAL ABSORPTION - a critical step
1. At physiological pH, vitamin C is mainly found in its ionized form, named ascorbate (Asc) and to a lesser extent in its oxidized form, called…
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Preparation of sustained-release tablets using a solventless-mixing tablet coating technique:…
The aim of this study was to produce sustained-release tablets by V-shaped blending of polymer and tablets without using solvents or heating, and we investigated the design of polymer particles with high coating performance by modifying the structure of the particles using sodium lauryl sulfate.…
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Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications
Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to…
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Development and Characterization of Chitosan-Based-Spray-Dried Solid Dispersions of Apigenin: 3D…
This study aimed to develop chitosan-based apigenin spray dried solid dispersion using 1:1,1:1.5,1:2 w/w ratios. The results of process yield and drug assay were found to be (87.5%, 94.2%, and 95.86%), (95.2 ±1.34%), (99.5 ±0.85%), and (97.6 ±2.42%), respectively, for AC1, AC2, and AC3. Flow…
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Considering inelasticity in the real-time monitoring of particle size for twin-screw granulation via…
A recently developed process analytical technology (PAT) using artificial intelligence to form the framework of its model, combining frequency-domain acoustic emissions (AE) and elastic impact mechanics to accurately predict complex particle size distributions (PSD) in real-time. This model was…
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High-performance nanomesh-structured cellulose as a versatile pharmaceutical excipient
Biocompatible cellulose has been used as a pharmaceutical excipient for several decades. However, there are still shortcomings, such as low drug loading, slow disintegration, and easy drug extraction. Herein, we describe a novel process for manufacturing cellulose nanomesh (CNM), a new structured…
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