Pharma Excipients
Sweeteners
Pediatric dosage forms—challenges and recent developments: A critical review
Pediatric population is a diverse group comprising of different subgroups. The use of unlicensed and off-label medicines for treating children is widespread due to the non-availability of suitable dosage forms for this age group. Although the physiological differences related to the diverse age…
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Rheological & Suspending Properties of Commonly Used Oral Suspending Vehicles
Little is documented about the rheology of commonly oral used suspending vehicles (which include everything from water through commercial suspending agents to semi-solid foods such as yoghurt which are often used in the administration of medicines to children). Following on from this, little is…
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Simultaneous taste-masking and oral bioavailability enhancement of Ligustrazine by forming sweet…
Ligustrazine (or Tetramethylpyrazine, TMP) is an active pharmaceutical ingredient that faces the challenges of bitter taste and low oral bioavailability by the commercial phosphate salt (TMP-Pho). We tackled these challenges by forming salts with two sweeteners, acesulfame (Acs) and saccharine…
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Organoleptic excipients used in pediatric antibiotics
Taste is a crucial factor that determines the palatability of the oral dosage form and patient compliance.
Objective
The aim of this work was to evaluate the organoleptic excipients in oral antibiotics for pediatric use marketed in Brazil.
Methods
The information was obtained from the…
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Controlled dissolution of freeform 3D printed carbohydrate glass scaffolds in hydrogels using a…
Freeform 3D printing combined with sacrificial molding promises to lead advances in production of highly complex tubular systems for biomedical applications. Here we leverage a purpose-built isomalt 3D printer to generate complex channel geometries in hydrogels which would be inaccessible with other…
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Selection Of A Filler For Tablets Manufactured With Direct Compression Method Containing Dry Ginger…
The preliminary studies of physico-chemical and pharmaco-technological properties of the dry extract of ginger have determined the need for introduction of different groups of excipients for developing a solid dosage form for the treatment of type II diabetes mellitus.
Aim: To choose the rational…
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The influence of isomalt particle morphology on tabletability after roll compaction/dry granulation
The influence of different isomalt particle morphologies on dry granule and tablet properties was investigated. Primary crystals, milled particles and agglomerates were tableted after roll compaction/dry granulation and compared to the directly compressed powders. Afterwards, the changes in…
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Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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Freeze/thaw of IGG solutions
In this communication, the effect of mannitol and trehalose crystallization on the unfolding of IgG1, a monoclonal antibody, in the frozen state with repeat freeze/thaw under different pH conditions was explored. Formulations were annealed at −20 °C for 20 h five times (interrupted by freeze/thaw).…
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Pharmaceutical preformulation studies and paediatric oral formulations of sodium dichloroacetate
The purpose of this study was to develop liquid and solid paediatric formulations of sodium dichloroacetate (DCA) for the treatment of congenital lactic acidosis (CLA). In this work preformulation studies on the active molecule were performed to identify those physico-chemical properties of the drug…
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