excipients

Suppliers of pharmaceuticals and excipients face challenges in controlling technically unavoidable particles (TUPs) to prevent defects and protect brand reputation. Ceolus™,  Asahi Kasei´s microcrystalline cellulose (MCC) products demonstrate exceptionally low levels of TUPs thanks to their…
Read More...

What were the reasons for developing a new disintegrant premix based on natural ingredients? For years, we have seen an increased interest in a healthy lifestyle on the consumer side. Not only in the USA, but also in Europe, consumers increasingly want to avoid chemical or synthetic ingredients and…
Read More...

Would Nanocarriers Complement Biofilm Disruption or Pave Its Road? Introduction: Cystic fibrosis (CF) is associated with pulmonary Pseudomonas aeruginosa infections persistent to antibiotics. Methods: To eradicate pseudomonal biofilms, solid lipid nanoparticles (SLNs) loaded with…
Read More...

Bedaquiline fumarate (BQF) is classified as a BCS class II drug and has poor water solubility and dissolution rate, which ultimately compromises bioavailability. The objective of this study is to improve the biopharmaceutical properties of BQF through a solid dispersion system by using Soluplus®.…
Read More...

STYL’ONE EVO TABLETING INSTRUMENT The all-in-one multi-functional R&D press from early API characterization and formulation to scale-up at production speed The most advanced R&D press designed as multifunction tool adapted to every demanding need from early research to production support…
Read More...

INTRODUCTION Ultrafiltration/diafiltration (UF/DF) is an integral part of every biotherapeutic downstream process. A typical UF/DF process requires several passes through the pump and the membrane cassette, often taking several hours for completion. During this time, proteins are exposed to several…
Read More...

Abstract The aim of this study was to investigate how the propensity for aerosolisation in binary adhesive mixtures was affected by the drug load, and to determine whether these findings could be linked to different blend states. Binary blends of two different lactose carriers, each with varying…
Read More...

Abstract TPGS (D-α-tocopheryl polyethylene glycol 1000 succinate) polymeric micelles show interesting properties for ocular administration thanks to their solubilization capability, nanometric size and tissue penetration ability. However, micelles formulations are generally characterized by low…
Read More...

The goal of this study was to formulate tacrolimus nanogel based on nanostructured lipid carrier (NLC) in order to improve the efficacy, aesthetic, and patient compliance for the treatment of psoriasis. The microemulsion method was used to create phase diagrams and NLCs were prepared using points…
Read More...

Abstract Parenteral administration is one of the most commonly used drug delivery routes for nanoparticle-based dosage forms, such as lipid-based and polymeric nanoparticles. For the treatment of various diseases, parenteral administration include intravenous, subcutaneous, and intramuscular…
Read More...