excipients

Introduction Granulation of powder blends is a commonly applied technique for pharmaceutical formulations which have no suitable flowability or compactability or are inhomogeneous with regards to the API content. Mainly wet granulation is applied3 and here, especially continuous twin-screw…
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Oral dispersible tablets (ODTs) are patient compliant dosage forms which rapidly disintegrate in the mouth following active absorption with rapid onset of action. The current study was designed to resolve compression problems used for ODTs, as high compression force exhibited hardness and drug…
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Abstract Exposing the hydrated-soft-starch matrix of intact grain or reconstituted flour dough to a high-temperature-short-time (HTST) leads to rapid vapor generation that facilitates high-pressure build-up in its elastic matrix linked to large deformation and expansion. The expanded starch matrix…
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Arteether (ART), an antimalarial drug, belongs to BCS class II and has very low oral bioavailability. Clinically, it is given as a solution in oil by the intramuscular route. Solid dispersion in Soluplus or Kollicoat IR, two commonly used grafted copolymers, may improve its in vitro dissolution and…
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Abstract The production of hollow solid micro- and nanoparticles using fully hydrogenated soybean oil (FHSO) and supercritical carbon dioxide (SC-CO2) has been studied in the literature. This research aimed to examine the impact of FHSO volumes (10 to 50 ml), temperatures (60 to 80 °C), and…
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The bioavailability of lapatinib ditosylate, an active anticancer agent against breast neoplasms, is constrained by its poor bioavailability due to poor aqueous solubility. So, the study’s objective was to develop its nanocrystalline solid dispersion (NSD) in order to improve its oral…
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Abstract Insulin therapy is the mainstay to treat diabetes characterizedd by hyperglycemia. However, its short half-life of only 4–6 min limits its effectiveness in treating chronic diabetes. Advances in recombinant DNA technology and protein engineering have led to several insulin analogue…
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This article is part of the issue: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE OF THE CHINESE RHEUMATOLOGISTS (ICCR) 25–26 November 2023 Abstract Background Ketoprofen (KPN) is commonly prescribed drug to alleviate pain related with rheumatoid arthritis (RA).…
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Skin cancer chemotherapeutics often lead to the development of severe cytotoxicity, compelling the development of novel delivery systems to not only enhance therapeutic efficacy but also minimize side effects and improve patient compliance. In recent years, topical nanoemulsions have emerged as…
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Catechin is a naturally occurring flavonoid of the flavan-3-ol subclass with numerous biological functions; however, these benefits are diminished due to several factors, including low water solubility and degradation in the stomach's harsh environment. So, this study aimed to develop an intelligent…
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